{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:11:22Z","timestamp":1780481482524,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NIH 1R01HL079937"],"award-info":[{"award-number":["NIH 1R01HL079937"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000317","name":"Action Medical Research","doi-asserted-by":"publisher","award":["GN2509"],"award-info":[{"award-number":["GN2509"]}],"id":[{"id":"10.13039\/501100000317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001279","name":"Great Ormond Street Hospital Charity","doi-asserted-by":"publisher","award":["V4615"],"award-info":[{"award-number":["V4615"]}],"id":[{"id":"10.13039\/501100001279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["IS\u2010BRC\u20101215\u201020\u2009012"],"award-info":[{"award-number":["IS\u2010BRC\u20101215\u201020\u2009012"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000364","name":"Stroke Association","doi-asserted-by":"publisher","award":["PF23\\100015"],"award-info":[{"award-number":["PF23\\100015"]}],"id":[{"id":"10.13039\/501100000364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Sleep\u2010disordered breathing (SDB) and cognitive challenges are commonly observed in children living with sickle cell anaemia (SCA). This study investigated the longitudinal change in polysomnographic outcomes and the association with cognitive functions in children living with SCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Data from the Sleep Asthma Cohort (SAC 1, 2 and 3) included participants living with SCA (aged 4\u201318\u2009years) who were initially recruited between 2006 and 2009, with follow\u2010up studies conducted through until 2019. Polysomnographic indices (PSG indices), that is, obstructive apnoea hypopnoea index (OAHI), central apnoea index (CAI), mean overnight oxygen saturation and total sleep time, were assessed over two visits. Additional analyses assessed the impact of PSG indices on cognitive outcomes collected at Visit 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety\u2010two participants (91 HbSS, 1HbS\u03b2) completed a PSG at Visit 1 and 56 participants returned for Visit 2, 40 of whom returned for the Visit 3 cognitive assessment; mean ages were 9.9 (3.8), 14.7 (3.69) and 17.7 (4.64) years, respectively. Total sleep time significantly decreased between the two visits, while overall PSG indices remained stable. Mean overnight oxygen saturation at Visit 1 significantly predicted working memory at Visit 3. In addition, CAI at Visit 2 was associated with lower scores on the verbal comprehension index and self or caregiver\u2010reported measures of executive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PSG indices did not change significantly over time; however, at least one PSG screening is recommended, given the complexity of sickle pathology. Overnight oxygen saturation levels and central apnoea influence cognitive outcomes for children living with SCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70051","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:01:17Z","timestamp":1771830077000},"page":"520-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Longitudinal Analysis of Sleep\u2010Disordered Breathing and Cognitive Outcomes in Children Living With Sickle Cell Anaemia"],"prefix":"10.1111","volume":"51","author":[{"given":"Shifa","family":"Hamdule","sequence":"first","affiliation":[{"name":"Developmental Neurosciences Unit and NIHR Biomedical Research Centre UCL Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Koelbel","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Unit and NIHR Biomedical Research Centre UCL Great Ormond Street Institute of Child Health  London UK"},{"name":"Sleep Education and Research Laboratory UCL Institute of Education  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna C.","family":"Gavlak","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Unit and NIHR Biomedical Research Centre UCL Great Ormond Street Institute of Child Health  London UK"},{"name":"Clinical and Experimental Sciences University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sati","family":"Sahota","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Unit and NIHR Biomedical Research Centre UCL Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2443-7958","authenticated-orcid":false,"given":"Fenella J.","family":"Kirkham","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Unit and NIHR Biomedical Research Centre UCL Great Ormond Street Institute of Child Health  London UK"},{"name":"Clinical and Experimental Sciences University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Hood","sequence":"additional","affiliation":[{"name":"Division of Psychology and Mental Health, Manchester Centre for Health Psychology University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.10233"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsz031"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005644"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2022.06.010"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13113"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630269.2023.2290507"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30638"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202205-380ST"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617711001469"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565641.2022.2038601"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617719000730"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-4223"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.106566"},{"key":"e_1_2_11_15_1","volume-title":"International Classification of Sleep Disorders: Diagnostic & Coding Manual","author":"AAoS Medicine","year":"2005"},{"key":"e_1_2_11_16_1","volume-title":"Review of the Wechsler Abbreviated Scale of Intelligence (WASI\u2010II)","author":"McCrimmon A. W.","year":"2013"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.05.006"},{"issue":"6","key":"e_1_2_11_18_1","first-page":"843","article-title":"Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society","volume":"38","author":"Watson N. F.","year":"2015","journal-title":"Sleep"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjorl.2021.05.001"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2150"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1392"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa287"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2022.05.015"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008721"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-04-841247"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2022.819412"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/23982128211007769"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10120981"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.004"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpnec.2022.100128"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.005215"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31531"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/coa.70051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:23:26Z","timestamp":1780478606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.70051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,22]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/coa.70051"],"URL":"https:\/\/doi.org\/10.1111\/coa.70051","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.70051\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70051\/v1\/review1","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.22541\/au.174071721.18195185\/v1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,22]]},"assertion":[{"value":"2025-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}