{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:51:47Z","timestamp":1787795507201,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify sociodemographic and clinical predictors of symptom severity and quality of life (QoL) impairment in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), diagnosed according to the latest EPOS 2020 criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional analytical study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary Care Center (University Hospital of Ja\u00e9n, Spain).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 188 patients diagnosed with CRSwNP were evaluated. Symptom severity and QoL were assessed using the Nasal Obstruction Symptom Evaluation (NOSE\u2010E) and the Sino\u2010Nasal Outcome Test (SNOT\u201022). Multiple linear regression analysis was used to identify predictors of symptom burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher body mass index (BMI) and the presence of sleep apnoea were independently associated with increased symptom severity, as measured by both the NOSE\u2010E (adj.\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.224,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and the SNOT\u201022 (adj.\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.242,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). Smoking was associated in the bivariate analysis but was not retained in the multivariate models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BMI and sleep apnoea are independent predictors of greater symptom burden and poorer QoL in CRSwNP. These findings highlight the importance of incorporating weight management and sleep apnoea screening into the multidisciplinary management of CRSwNP to improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70058","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T07:16:48Z","timestamp":1762413408000},"page":"275-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Modifiable Risk Factors for Symptom Burden in Chronic Rhinosinusitis With Nasal Polyps: The Role of Obesity and Sleep Apnoea"],"prefix":"10.1111","volume":"51","author":[{"given":"Javier Modesto","family":"Garc\u00eda\u2010Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Health Sciences University of Ja\u00e9n  Ja\u00e9n Spain"},{"name":"Department of Otolaryngology Hospital Universitario de Ja\u00e9n  Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Soledad","family":"S\u00e1nchez\u2010Torices","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Ja\u00e9n  Ja\u00e9n Spain"},{"name":"Department of Otolaryngology Hospital Universitario de Ja\u00e9n  Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Pilar","family":"G\u00f3mez\u2010Gallego","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Ja\u00e9n  Ja\u00e9n Spain"},{"name":"Department of Otolaryngology Hospital Universitario de Ja\u00e9n  Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Feliz\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Ja\u00e9n  Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Alharilla","family":"Montilla\u2010Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Ja\u00e9n  Ja\u00e9n Spain"},{"name":"Department of Otolaryngology Hospital Universitario de Ja\u00e9n  Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Lomas\u2010Vega","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Ja\u00e9n  Ja\u00e9n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"},{"issue":"29","key":"e_1_2_10_3_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"Fokkens W. J.","year":"2020","journal-title":"Rhinology"},{"issue":"34","key":"e_1_2_10_4_1","first-page":"1","article-title":"Outcome Measures for Chronic Rhinosinusitis With Nasal Polyps","volume":"62","author":"Sedaghat A. R.","year":"2024","journal-title":"Journal of Rhinology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.03.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-047230"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041391"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-024-01184-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S290424"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.716"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.21053\/ceo.2020.02250"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00510-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino14.137"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3437-0"},{"key":"e_1_2_10_15_1","first-page":"50","article-title":"Eosinophilia, Asthma, NERD and the Use of Oral Corticosteroids Predict Uncontrolled Chronic Rhinosinusitis With Nasal Polyps After Surgery","volume":"42","author":"Penttil\u00e4 E.","year":"2024","journal-title":"Asian Pacific Journal of Allergy and Immunology"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2012.05.002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.556746"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22678"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924231153483"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.10.016"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13984"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.01.048"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111540"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2024.104310"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin17.255"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/coa.70058","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:37:04Z","timestamp":1771051024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.70058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/coa.70058"],"URL":"https:\/\/doi.org\/10.1111\/coa.70058","archive":["Portico"],"relation":{},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]},"assertion":[{"value":"2025-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}