{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:07:49Z","timestamp":1771052869178,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the efficacy of platelet\u2010rich plasma (PRP), a biologic agent that facilitates tissue regeneration and wound healing, in improving postoperative outcomes of frontal sinus ostium (FSO) and need for postoperative intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A prospective, randomised controlled trial included chronic rhinosinusitis (CRS) patients undergoing bilateral endoscopic frontal sinus surgery. PRP\u2010soaked absorbable hemostat was applied to the frontal sinus ostium on the randomised side, while a plain absorbable hemostat was used on the control side. Endoscopic evaluations were conducted intraoperatively (baseline), and at 30 and 90\u2009days postoperatively to assess the FSO area, FSO patency, inflammatory visual analog scale (VAS) score, presence of polypoid edema, adhesion\/scarring grade, and the need for postoperative interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty participants were enrolled and PRP was applied to 30 frontal sinus ostia on randomised side. On 30\u2010day post\u2010ESS PRP significantly improved inflammatory VAS score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041), reduced polypoid edema (odds ratio (OR) 0.49; 95% CI: 0.24, 0.98) and adhesion scarring (OR 0.33; 95% CI: 0.15, 0.74), and improved the need of postoperative intervention compared to the control (risk ratio (RR) 0.25; 95% CI: 0.11, 0.58). On 90\u2010day post\u2010ESS, PRP significantly reduced polypoid edema (OR 0.35; 95% CI: 0.17, 0.67), and adhesion scarring (OR 0.20; 95% CI 0.07, 0.52) compared to the control. The FSO area changes and patency grade were not significantly different between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The PRP application following frontal sinusotomy improved the inflammatory VAS score, polypoid edema and adhesion scarring grades, and reduces the need for oral steroid intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70062","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T23:29:42Z","timestamp":1764026982000},"page":"296-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Platelet\u2010Rich Plasma (\n                    <scp>PRP<\/scp>\n                    ) on Post\u2010Surgical Outcomes Following Endoscopic Frontal Sinusotomy: A Randomised Controlled Trial."],"prefix":"10.1111","volume":"51","author":[{"given":"Pattranit","family":"Pakpattaraphaiboon","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine Vajira Hospital, Navamindradhiraj University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kawinyarat","family":"Jitaroon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine Vajira Hospital, Navamindradhiraj University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7043-139X","authenticated-orcid":false,"given":"Suphakrit","family":"Limpornpugdee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine Vajira Hospital, Navamindradhiraj University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0726-x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21132"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00006"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065897781446793"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2016.03.024"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22238"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21136"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400507"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.111705"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2023.12.003"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.14186"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000513099"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43163-024-00703-4"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08483-6"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/pajr.pajr_9_20"},{"key":"e_1_2_12_17_1","article-title":"Determining the Effect of Platelet\u2010Rich Plasma (PRP) on Improving Endoscopic Sinus Surgery: A Randomized Clinical Trial Study (RCT)","volume":"33","author":"Mohebbi A.","year":"2019","journal-title":"Medical Journal of the Islamic Republic of Iran"},{"issue":"12","key":"e_1_2_12_18_1","article-title":"Efficacy of Platelet\u2010Rich Plasma in Endoscopic Sinus Surgery for Chronic Sinusitis: A Systematic Review and Meta\u2010Analysis","volume":"16","author":"Bukhari J. 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