{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:39:24Z","timestamp":1775450364704,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n House dust mite (HDM) allergy significantly impacts quality of life. Allergen immunotherapy (AIT), specifically sublingual immunotherapy (SLIT), is an effective treatment for HDM allergy, but adherence to SLIT remains a challenge. This study aimed to evaluate the impact of adherence to SLIT on the use of allergy medications, including antihistamines, nasal corticosteroids, and inhaled corticosteroids (ICS) in a real\u2010world setting.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a nationwide cohort study using data from Denmark's comprehensive registries. Patients who initiated\n HDM SLIT<\/jats:styled-content>\n between 2015 and 2020 were included, with follow\u2010up through 2022. Adherent patients, defined as those obtaining at least 80% of the prescribed Defined Daily Dose (\n DDD<\/jats:styled-content>\n ) of\n SLIT<\/jats:styled-content>\n , were compared to non\u2010adherent patients. Medication use was tracked for antihistamines, nasal corticosteroids, and\n ICS<\/jats:styled-content>\n . Statistical analyses, including Probit and generalised linear models, assessed the likelihood of obtaining medications and the quantity dispensed, adjusted for age and sex.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 950 patients, 456 (48%) were classified as adherent. Adherent patients showed significantly reduced usage of antihistamines (\n p<\/jats:italic>\n \u2009<\u20090.001) and nasal corticosteroids (\n p<\/jats:italic>\n \u2009<\u20090.001) compared to non\u2010adherent patients. No significant differences were found in\n ICS<\/jats:styled-content>\n use or dosage. Additionally, adherent patients were more likely to have higher education levels and be married or cohabiting.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Adherence to\n SLIT<\/jats:styled-content>\n for\n HDM<\/jats:styled-content>\n allergy is associated with reduced use of antihistamines and nasal corticosteroids. These findings emphasise the importance of\n SLIT<\/jats:styled-content>\n adherence in managing\n HDM<\/jats:styled-content>\n allergy and suggest that improving adherence could further reduce medication usage, improving patient outcomes in real\u2010world settings.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.70083","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T03:24:41Z","timestamp":1767583481000},"page":"394-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adherence and Effect on Allergy Medication Use in Allergic Rhinoconjunctivitis Patients Treated With House Dust Mite Allergen Immunotherapy\u2014A Nationwide Cohort Study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6204-2623","authenticated-orcid":false,"given":"Morten","family":"Borg","sequence":"first","affiliation":[{"name":"Department of Medicine Lillebaelt Hospital Vejle, University Hospital of Southern Denmark Vejle Denmark"},{"name":"Department of Regional Health Research University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-3463","authenticated-orcid":false,"given":"Ole","family":"Hilberg","sequence":"additional","affiliation":[{"name":"Department of Medicine Lillebaelt Hospital Vejle, University Hospital of Southern Denmark Vejle Denmark"},{"name":"Department of Regional Health Research University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke","family":"Ibsen","sequence":"additional","affiliation":[{"name":"i2 Minds Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"L\u00f8kke","sequence":"additional","affiliation":[{"name":"Department of Medicine Lillebaelt Hospital Vejle, University Hospital of Southern Denmark Vejle Denmark"},{"name":"Department of Regional Health Research University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"issue":"4","key":"e_1_2_13_2_1","first-page":"211","article-title":"Geography of House Dust Mite Allergens","volume":"28","author":"Thomas W. 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