{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:39:20Z","timestamp":1775450360217,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cystic fibrosis (CF) patients often contend with chronic rhinosinusitis with nasal polyposis (CRSwNP), with higher relapse rates after surgery compared to non\u2010CF individuals. CRSwNP has a significant impact on their quality of life and increases pulmonary infections risk. Traditional medical and surgical interventions are frequently inadequate. Dupixent is endorsed for persistent CRSwNP following conventional treatment in non\u2010CF subjects; its effectiveness in CF patients remains unexplored considering that those patients are frequently affected by mixed endotypes of CRS with some type\u20102 features. This study delves into the assessment of Dupixent in CF\u2010related CRSwNP and compares it with a matched control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a non\u2010randomised single\u2010centre trial enrolling CF patients and non\u2010CF controls. SNOT\u201022 and NPS scores before, 1 and 6\u2009months after therapy were documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dupixent exhibited a significant reduction in SNOT\u201022 scores after 6\u2009months in both CF and control groups (\n                      <jats:italic>V<\/jats:italic>\n                      \u2009=\u200921,\n                      <jats:italic>p<\/jats:italic>\n                      value\u2009=\u20090.031, both). While NPS scores showed non\u2010significant improvement in CF, the control group experienced a notable reduction after 6\u2009months (\n                      <jats:italic>V<\/jats:italic>\n                      \u2009=\u200910, both;\n                      <jats:italic>p<\/jats:italic>\n                      value\u2009=\u20090.10;\n                      <jats:italic>p<\/jats:italic>\n                      value\u2009=\u20090.034, respectively). No statistical differences were observed between CF and control groups in SNOT\u201022 and NPS scores after 6\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This pilot study observed Dupixent's potential in managing CRSwNP in CF patients since SNOT\u201022 improvement was statistically significant and comparable to the non\u2010CF patients. Although NPS scores improved without statistical significance, no differences emerged between CF and control groups. Therefore, Dupixent achieved comparable results between CF and non\u2010CF patients suffering from CRSwNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70084","type":"journal-article","created":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T23:54:42Z","timestamp":1768175682000},"page":"409-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dupixent's Efficacy in Cystic Fibrosis Related Chronic Rhinosinusitis With Nasal Polyposis: A Pilot Study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8762-3731","authenticated-orcid":false,"given":"Piero Giuseppe","family":"Meliante","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Mental Health and Sensory Organs (NESMOS) Faculty of Medicine and Psychology, \u201cSant'Andrea\u201d Hospital, \u201cSapienza\u201d University  Rome Italy"},{"name":"Department of Sense Organs Faculty of Medicine and Dentistry, \u201cUmberto I\u201d Policlinic, \u201cSapienza\u201d University  Rome Italy"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery \u2013 Azienda Ospedaliera dei Colli \u201cV. Monaldi\u201d Hospital  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Covelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mental Health and Sensory Organs (NESMOS) Faculty of Medicine and Psychology, \u201cSant'Andrea\u201d Hospital, \u201cSapienza\u201d University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Cimino","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine Faculty of Medicine and Dentistry, \u201cUmberto I\u201d Policlinic, \u201cSapienza\u201d University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Altomari","sequence":"additional","affiliation":[{"name":"Department of Sense Organs Faculty of Medicine and Dentistry, \u201cUmberto I\u201d Policlinic, \u201cSapienza\u201d University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9194-1444","authenticated-orcid":false,"given":"Irene","family":"Fatuzzo","sequence":"additional","affiliation":[{"name":"Department of Sense Organs Faculty of Medicine and Dentistry, \u201cUmberto I\u201d Policlinic, \u201cSapienza\u201d University  Rome Italy"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery \u2013 Azienda Ospedaliera dei Colli \u201cV. Monaldi\u201d Hospital  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Filippi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mental Health and Sensory Organs (NESMOS) Faculty of Medicine and Psychology, \u201cSant'Andrea\u201d Hospital, \u201cSapienza\u201d University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Bandiera","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Mental Health and Sensory Organs (NESMOS) Faculty of Medicine and Psychology, \u201cSant'Andrea\u201d Hospital, \u201cSapienza\u201d University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-7607","authenticated-orcid":false,"given":"Antonella","family":"Polimeni","sequence":"additional","affiliation":[{"name":"Oral and Maxillo Facial Sciences Department, Faculty of Medicine and Dentistry \u201cUmberto I\u201d Policlinic, \u201cSapienza\u201d University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Sense Organs Faculty of Medicine and Dentistry, \u201cUmberto I\u201d Policlinic, \u201cSapienza\u201d University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"de Vicentiis","sequence":"additional","affiliation":[{"name":"Department of Sense Organs Faculty of Medicine and Dentistry, \u201cUmberto I\u201d Policlinic, \u201cSapienza\u201d University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Bertin","sequence":"additional","affiliation":[{"name":"Department of Sense Organs Faculty of Medicine and Dentistry, \u201cUmberto I\u201d Policlinic, \u201cSapienza\u201d University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2022.10.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00576-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444959"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199608000-00018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2019.12.008"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201312-2129PP"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.03.002"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90183-3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.27193"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"605","article-title":"Chronic Rhinosinusitis in Patients With Cystic Fibrosis","volume":"4","author":"Hamilos D. 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