{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:58:32Z","timestamp":1785776312047,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000664","name":"Health Technology Assessment Programme","doi-asserted-by":"publisher","award":["12\/146\/06"],"award-info":[{"award-number":["12\/146\/06"]}],"id":[{"id":"10.13039\/501100000664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The National Trial of Tonsillectomy in Adults (NATTINA) demonstrated that tonsillectomy is clinically and cost\u2010effective; however, the generalizability of the results to a real\u2010world population remains uncertain. The number of episodes of tonsillitis is used to assess candidacy for tonsillectomy. An alternative approach could be to utilise a patient\u2010reported outcome measure such as the Tonsillectomy Outcome Inventory\u201014 (TOI\u201014).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the TOI\u201014 scores in a real\u2010world clinical cohort with the NATTINA cohort. To assess the relationship between the TOI\u201014 and the number of sore throat days. To assess the role of socioeconomic status in recurrent tonsillitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline TOI\u201014 scores, the relationship between the number of sore throat days and TOI\u201014 scores, and socioeconomic deprivation were compared between a real\u2010world clinical cohort and the NATTINA population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Individuals declining entry into NATTINA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009609) had the highest TOI\u201014 score (48.3 (SD 9.9)), followed by the clinical cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009422) (43.9 (SD 13.3)) and then the randomised NATTINA population (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009452) (43.1 (SD 12.0),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The correlation between the number of sore throat days and baseline TOI\u201014 score in all participants was very weak, 0.114,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001. Approximately 50% of participants with recurrent tonsilitis reside in areas ranked from deciles 1 to 3 on the Scottish\/English Index of Multiple Deprivation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings from NATTINA can be applied to general clinical practice. The use of a patient\u2010reported outcome measurement instead of sore throat episodes as a criterion for tonsillectomy candidacy requires further research and should consider the impact of socioeconomic status on tonsillitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70116","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:24:13Z","timestamp":1778498653000},"page":"672-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["How Does the Morbidity of Sore Throat in Recurrent Tonsillitis Correlate With the Tonsillitis Outcome Inventory\u201014 (\n                    <scp>TOI<\/scp>\n                    \u201014)?"],"prefix":"10.1111","volume":"51","author":[{"given":"Pavithran","family":"Maniam","sequence":"first","affiliation":[{"name":"Ear, Nose &amp; Throat Department Newcastle Upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona M.","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/ENT Surgery NHS Greater Glasgow and Clyde  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Fouweather","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute Newcastle University  Newcastle upon Tyne UK"},{"name":"Biostatistics Research Group Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Dawn","family":"Teare","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute Newcastle University  Newcastle upon Tyne UK"},{"name":"Biostatistics Research Group Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Wilson","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"O'Hara","sequence":"additional","affiliation":[{"name":"Ear, Nose &amp; Throat Department Newcastle Upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"},{"name":"Population Health Sciences Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Management of Sore Throat and Indications for Tonsillectomy","year":"2010"},{"key":"e_1_2_11_3_1","unstructured":"\u201cSore Throat\u2014Acute: Scenario: Management \u201dhttps:\/\/cks.nice.org.uk\/topics\/sore\u2010throat\u2010acute\/management\/management\/."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019184"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2020.7030"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198403153101102"},{"key":"e_1_2_11_7_1","volume-title":"Management of Sore Throat and Indications for Tonsillectomy","author":"Royal College of Physicians","year":"1999"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1258\/002221504323086543"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106\u2010012\u20102545\u20107"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)00519\u20106"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3310\/YKUR3660"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2022-323910"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215122001384"},{"key":"e_1_2_11_14_1","unstructured":"\u201cSIMD (Scottish Index of Multiple Deprivation) \u201daccessed 28 March 2025 https:\/\/simd.scot\/#\/simd2020\/BTTTFTT\/9\/\u20104.0000\/55.9000\/."},{"key":"e_1_2_11_15_1","unstructured":"\u201cEnglish Indices of Deprivation 2019: Postcode Lookup \u201daccessed 28 March 2025 https:\/\/imd\u2010by\u2010postcode.opendatacommunities.org\/imd\/2019."},{"key":"e_1_2_11_16_1","volume-title":"Study Guide for Evans' Straightforward Statistics for the Behavioral Sciences","author":"Hensch S. 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