{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:58:30Z","timestamp":1785776310869,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n This study aims to investigate the effects of oxymetazoline on the time required for the bronchoscope to reach the vocal cords, nasal manipulation difficulty during bronchoscopy, nasal mucosal injury, and patient\u2010reported pain in individuals with turbinate hypertrophy undergoing bronchoscopic examination.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n This prospective, double\u2010blinded, randomised controlled trial enrolled 240 patients with turbinate hypertrophy (November 2023 to July 2024), randomised into oxymetazoline, saline, and blank control groups (\n n<\/jats:italic>\n \u2009=\u200980 each). The primary outcome was bronchoscope\u2010to\u2010vocal\u2010cords time. Secondary outcomes included operator\u2010assessed nasal passage ease (negotiation visual analog scale [VAS]), assistant\u2010evaluated facial pain (Facial Pain Scale), patient\u2010reported nasal pain (Pain VAS), operator\u2010rated mucosal trauma (Trauma VAS) and hemodynamic parameters.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The oxymetazoline group demonstrated significantly shorter bronchoscope\u2010to\u2010vocal\u2010cords time compared to the saline group (44.00\u2009s [41.00\u201347.00] vs. 52.00\u2009s [50.00\u201358.00],\n p<\/jats:italic>\n \u2009<\u20090.001), improved nasal passage ease (negotiation VAS: 3.00 [2.00\u20134.00] vs. 5.00 [4.00\u20136.00],\n p<\/jats:italic>\n \u2009<\u20090.001), and reduced mucosal trauma (Trauma VAS: 7.00 [6.00\u20138.00] vs. 9.00 [8.00\u20139.00],\n p<\/jats:italic>\n \u2009<\u20090.001). Patients receiving oxymetazoline reported lower nasal pain scores (assistant\u2010assessed: 4.00 [3.00\u20135.00] vs. 5.00 [5.00\u20136.00]; patient\u2010reported: 4.00 [3.00\u20134.75] vs. 5.50 [5.00\u20136.00], both\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Oxymetazoline optimises bronchoscopy in turbinate hypertrophy patients by shortening procedural time, easing nasal passage, mitigating mucosal injury, and alleviating pain. This trial is registered at\n chictr.org.cn<\/jats:ext-link>\n (ChiCTR2300077642).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/coa.70118","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:50:01Z","timestamp":1782467401000},"page":"770-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxymetazoline Can Shorten the Time Required for a Bronchoscope to Reach the Vocal Cords in Patients With Turbinate Hypertrophy"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9744-8537","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The First People's Hospital of Huoqiu County Lu'an Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanliang","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Chaohu Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac789"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103587"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002006"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.10.016"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40896"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.34133\/cbsystems.0013"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26043"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000001127"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_417_17"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000458"},{"issue":"2","key":"e_1_2_12_12_1","first-page":"148","article-title":"Topical Nasal Anaesthesia for Fibreoptic Bronchoscopy: Lignocaine Spray or Gel?","volume":"34","author":"Zainudin B. M.","year":"1993","journal-title":"Singapore Medical Journal"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680020366"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2020.101961"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.9.814"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin17.150"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl\u20102011\u2010200713"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23094"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000590"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin23.285"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/coa.70118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:34:35Z","timestamp":1785774875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.70118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/coa.70118"],"URL":"https:\/\/doi.org\/10.1111\/coa.70118","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.70118\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70118\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"assertion":[{"value":"2025-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}