{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:58:37Z","timestamp":1785776317689,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The haemoglobin\u2013albumin\u2013lymphocyte\u2013platelet (HALP) score is an inflammation\u2010 and nutrition\u2010related biomarker derived from routine blood tests, but its prognostic value in head and neck cancer (HNC) has not been quantitatively synthesized. This systematic review and meta\u2010analysis aimed to evaluate the association between pretreatment HALP and survival outcomes in HNC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase and Web of Science were searched to 24 January 2026 for cohort studies reporting hazard ratios (HRs) for survival outcomes by pretreatment HALP in HNC. Reviews, case reports, conference abstracts without full text, and studies lacking survival data were excluded. Random\u2010effects meta\u2010analysis was performed and risk of bias was assessed using QUIPS. The review was prospectively registered in the Open Science Framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six retrospective cohort studies (1759 patients) were included. Higher pretreatment HALP was associated with improved overall survival (pooled HR 0.52, 95% CI 0.41\u20130.67;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200917.6%) and disease\u2010free survival (pooled HR 0.60, 95% CI 0.47\u20130.76;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0%). After excluding the metastatic cohort, the pooled overall survival estimate remained similar (HR 0.56, 95% CI 0.45\u20130.70;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.0%), and leave\u2010one\u2010out analyses showed stable estimates (HR range 0.48\u20130.56).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher pretreatment HALP is associated with favourable survival in HNC. However, reported cutoff values for HALP have been inconsistent across studies. HALP might be helpful for clinicians in evaluating the prognosis of HNC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70134","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T02:16:01Z","timestamp":1782094561000},"page":"635-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of the Haemoglobin\u2013Albumin\u2013Lymphocyte\u2013Platelet Score in Head and Neck Cancer: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"51","author":[{"given":"Yu Hsin","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Cancer Center Far Eastern Memorial Hospital  New Taipei City Taiwan"},{"name":"Head and Neck Cancer Surveillance and Research Group Far Eastern Memorial Hospital  New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Head and Neck Cancer Surveillance and Research Group Far Eastern Memorial Hospital  New Taipei Taiwan"},{"name":"Department of Nursing Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Lun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Master Program of Big Data in Medical Healthcare Industry, College of Medicine Fu Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-1597","authenticated-orcid":false,"given":"Li\u2010Jen","family":"Liao","sequence":"additional","affiliation":[{"name":"Head and Neck Cancer Surveillance and Research Group Far Eastern Memorial Hospital  New Taipei Taiwan"},{"name":"Department of Otolaryngology Far Eastern Memorial Hospital  New Taipei City Taiwan"},{"name":"Department of Electrical Engineering Yuan Ze University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol33010030"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010021\u201007222\u20105"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24986"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.899518"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010025\u201009223\u20100"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27372"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2024.04.093"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14950"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20126"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S411194"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5629"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010615)91:12<2214::AID-CNCR1251>3.0.CO;2-P"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102891\u20109\u201069"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25324"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2022.01.003"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010018\u20104230\u2010z"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13264"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201096598\u20109"}],"container-title":["Clinical 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