{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:54:17Z","timestamp":1790934857961,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Laryngeal cancer incidence has risen globally, yet survival outcomes have shown limited improvement over recent decades. This study evaluated contemporary outcomes across multiple centres in Northern UK and examined stage\u2010 and treatment\u2010specific survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Multi\u2010centre retrospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting and Participants<\/jats:title>\n                    <jats:p>Data were collected for 2028 patients with biopsy\u2010proven squamous cell carcinoma of the larynx treated with curative intent between 2015 and 2021 across six tertiary head and neck cancer centres (Newcastle, Glasgow, Liverpool, Sheffield, Leeds, and Middlesbrough).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Overall survival (OS) and disease\u2010specific survival (DSS) were estimated using Kaplan\u2013Meier analysis and compared using log\u2010rank testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median follow\u2010up was 40\u2009months (mean age 66.8\u2009years; 81% male). Overall mortality was 41% and disease\u2010specific mortality 20%. Five\u2010year OS declined with advancing stage: 72.0% (T1), 54.5% (T2), 50.6% (T3), and 45.2% (T4). In unadjusted analyses, surgery in T1 disease was associated with higher survival (5\u2010year DSS 93.6% vs. 88.5%), while in advanced disease chemoradiotherapy was associated with the highest DSS (5\u2010year DSS 70.2%), although differences were not statistically significant. No significant differences in DSS were observed across year of diagnosis (2015\u20132021).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Survival outcomes for laryngeal cancer remain poor and have shown limited improvement over time. These findings provide important real\u2010world insights into contemporary outcomes and highlight the need for earlier detection, prevention strategies, and prospective collaborative research to improve future outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70138","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:23:14Z","timestamp":1783570994000},"page":"867-874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laryngeal Cancer Survival in Northern United Kingdom: A Multi\u2010Centre Retrospective Observational Study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9323-3107","authenticated-orcid":false,"given":"Amar","family":"Rajgor","sequence":"first","affiliation":[{"name":"National Institute for Health &amp; Care Research Doctoral Fellow in Otolaryngology, Population Health Sciences Institute, Newcastle University  Newcastle\u2010Upon\u2010Tyne UK"},{"name":"Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital  Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhona","family":"Hurley","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow &amp; Clyde  Newcastle\u2010Upon\u2010Tyne UK"},{"name":"Glasgow Head and Neck Research (GLAHNC) Group  Glasgow UK"},{"name":"CRUK Scotland Institute and School of Cancer Sciences, College of Medical and Veterinary Sciences, University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5564-1513","authenticated-orcid":false,"given":"Catriona M.","family":"Douglas","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow &amp; Clyde  Newcastle\u2010Upon\u2010Tyne UK"},{"name":"Glasgow Head and Neck Research (GLAHNC) Group  Glasgow UK"},{"name":"CRUK Scotland Institute and School of Cancer Sciences, College of Medical and Veterinary Sciences, University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Paterson","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow &amp; Clyde  Newcastle\u2010Upon\u2010Tyne UK"},{"name":"Glasgow Head and Neck Research (GLAHNC) Group  Glasgow UK"},{"name":"CRUK Scotland Institute and School of Cancer Sciences, College of Medical and Veterinary Sciences, University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Moor","sequence":"additional","affiliation":[{"name":"Leeds Teaching Hospitals NHS Foundation Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Lester","sequence":"additional","affiliation":[{"name":"South Tees Hospitals NHS Foundation Trust  Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sionis","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Davies","sequence":"additional","affiliation":[{"name":"Liverpool University Hospitals NHS Foundation Trust  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"O\u2019Hara","sequence":"additional","affiliation":[{"name":"Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital  Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-4253","authenticated-orcid":false,"given":"Gareth","family":"Inman","sequence":"additional","affiliation":[{"name":"NHS Greater Glasgow &amp; Clyde  Newcastle\u2010Upon\u2010Tyne UK"},{"name":"Glasgow Head and Neck Research (GLAHNC) Group  Glasgow UK"},{"name":"CRUK Scotland Institute and School of Cancer Sciences, College of Medical and Veterinary Sciences, University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Jones","sequence":"additional","affiliation":[{"name":"Liverpool University Hospitals NHS Foundation Trust  Liverpool UK"},{"name":"Liverpool Head &amp; Neck Centre  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Winston","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital  Newcastle\u2010Upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Northern Head & Neck Alliance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_3_1","unstructured":"CRUK \u201cHead and Neck Cancer Incidence Statistics \u201d2015 https:\/\/www.cancerresearchuk.org\/health\u2010professional\/cancer\u2010statistics\/statistics\u2010by\u2010cancer\u2010type\/head\u2010and\u2010neck\u2010cancers\/incidence#heading\u2010Four."},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031317"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2020.01.03"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-10318-1"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210499"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-067561"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-10557-8"},{"key":"e_1_2_13_11_1","first-page":"1","article-title":"Computed Tomography\u2010Based Radiomic Markers Are Independent Prognosticators of Survival in Advanced Laryngeal Cancer: A Pilot Study","volume":"138","author":"Rajgor A. D.","year":"2023","journal-title":"Journal of Laryngology and Otology"}],"container-title":["Clinical Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70138","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/coa.70138","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/coa.70138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:08:41Z","timestamp":1790932121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/coa.70138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/coa.70138"],"URL":"https:\/\/doi.org\/10.1111\/coa.70138","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/COA.70138\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70138\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70138\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/COA.70138\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1749-4478","1749-4486"],"issn-type":[{"value":"1749-4478","type":"print"},{"value":"1749-4486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"2024-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}