{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:54:32Z","timestamp":1790934872851,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study investigated the relationship between vestibular neuritis and various systemic inflammatory indices\u2014namely, neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), monocyte\u2010to\u2010lymphocyte ratio (MLR), systemic immune\u2010inflammation index (SII), and systemic inflammation response index (SIRI) and the clinical severity of vestibular neuritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 79 individuals were included: 41 patients with vestibular neuritis and 38 healthy controls. Systemic inflammatory parameters were calculated from complete blood count results, and their associations with disease severity\u2014classified as mild (\u2264\u20094\u2009days of nystagmus) or severe (&gt;\u20094\u2009days of nystagmus)\u2014were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NLR, SII and SIRI were significantly higher in the severe vestibular neuritis group compared to controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042, respectively), while the mild group showed no significant difference relative to either controls or the severe group. SII demonstrated the highest predictive value for severe vestibular neuritis (AUC\u2009=\u20090.66), showing superior discriminative performance compared with NLR and SIRI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although the pathogenesis of vestibular neuritis remains unclear, the elevation of NLR, SII and SIRI in more severe cases suggests an inflammatory involvement. Their association with severe disease may support future research into whether these markers could help identify patients who are more likely to benefit from anti\u2010inflammatory treatment strategies. However, further prospective studies are needed to clarify the clinical relevance of these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70140","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:08:08Z","timestamp":1783328888000},"page":"855-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Significance of Systemic Immune\u2010Inflammation and Inflammatory Response Indices in Vestibular Neuritis"],"prefix":"10.1111","volume":"51","author":[{"given":"Tu\u011fba","family":"Tulac\u0131","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Faculty of Medicine Balikesir University  Balikesir Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0861-5555","authenticated-orcid":false,"given":"Mustafa Utku","family":"Akba\u015f","sequence":"additional","affiliation":[{"name":"Department 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