{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:55:24Z","timestamp":1790934924744,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated demographic, clinical and perceptual factors associated with enrolment in a Phase III transoral surgical trial for HPV\u2010related oropharyngeal carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Single\u2010centre, questionnaire\u2010based cross\u2010sectional pilot study of patients screened for PATHOS trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary cancer centre participating in the PATHOS trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Patients with p16\u2010positive oropharyngeal carcinoma were eligible for the trial. Of 100 patients screened, 70 met trial eligibility and 51 completed a telephone questionnaire and were included. Inability to complete the questionnaire because of cognitive impairment or a language barrier was a prespecified survey exclusion criterion. However, no patient was excluded for either reason.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Primary outcome was the patient decision to enrol or decline participation in PATHOS (written consent). Predictor variables included demographic and clinical characteristics and responses to a 31\u2010item Likert\u2010scale questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 51 eligible patients who completed the questionnaire, 29 (57%) enroled in the trial. On univariable analysis, significant predictors included perceptions of treatment quality, toxicity, quality of life, travel distance, trial comprehension, randomisation, medical terminology, trust, prior trial experience and concern about being treated as a \u2018guinea pig\u2019. On multivariable analysis, prior trial experience (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) and not feeling like a \u2018guinea pig\u2019 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) remained significant, with travel distance trending (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.087).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Trial enrolment was driven primarily by prior exposure to clinical research and perceptions of vulnerability and trust, rather than by demographic or tumour factors. Addressing fears of being a \u2018guinea pig\u2019, improving trial comprehension and mitigating travel\u2010related barriers may enhance accrual and promote more equitable participation in head and neck cancer trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70160","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:55:19Z","timestamp":1787061319000},"page":"952-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Enrolment in a Transoral Surgical Trial for\n                    <scp>HPV<\/scp>\n                    \u2010Related Oropharyngeal Carcinoma"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-6329","authenticated-orcid":false,"given":"Nina","family":"Gallo","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1594-6424","authenticated-orcid":false,"given":"Caroline","family":"Casey","sequence":"additional","affiliation":[{"name":"Zucker School of Medicine at Hofstra\/Northwell  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5551-7785","authenticated-orcid":false,"given":"Andrea","family":"Costantino","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shravan","family":"Kandula","sequence":"additional","affiliation":[{"name":"AdventHealth Medical Group, Radiation Oncology Specialists  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Mekhail","sequence":"additional","affiliation":[{"name":"AdventHealth Cancer Institute  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0398-5442","authenticated-orcid":false,"given":"Xiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7527-3589","authenticated-orcid":false,"given":"J. 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