{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:54:17Z","timestamp":1790916857499,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Statins are considered a first\u2010line treatment for dyslipidaemia, being the most frequently prescribed medicine worldwide. However, statin therapy has been associated with several adverse effects, including statin\u2010associated myopathy, which may manifest with symptoms such as myalgia, muscle stiffness, and cramps. Because phonation involves skeletal muscles of the larynx, statin\u2010related muscular effects may also influence vocal function. The fundamental frequency of the voice (FFF) depends on vocal fold length, mass, and tension and may therefore reflect alterations in laryngeal muscle function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>In this prospective observational study, the authors analysed the FFF at the baseline (T0), before initiating statin therapy, and after 3\u2009months of treatment (T1). To measure the FFF, we have used a sensible microphone and the Multi\u2010Dimensional Voice Program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Thirty\u2010six adult patients (16 men and 20 women) have been initially enrolled, 28 of whom have successfully completed the study (12 men and 16 women).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 28 patients who have completed the 3\u2009months' study, 20 have had a reduction of the FFF. Of these, 14 have experienced mild muscle cramps, whereas 6 of them have not experienced any symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Changes in fundamental frequency were observed in a proportion of patients undergoing statin therapy. These findings suggest that acoustic voice analysis may potentially reflect alterations in laryngeal muscle function during statin treatment. However, given the limited sample size and the absence of a control group, further prospective studies with larger cohorts and controlled confounding factors are necessary to clarify the potential role of FFF as an objective marker of statin\u2010associated myopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70171","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:15:38Z","timestamp":1790914538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Voice Fundamental Frequency Variation and Statin Therapy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5316-8277","authenticated-orcid":false,"given":"Luca Francesco","family":"Parata","sequence":"first","affiliation":[{"name":"Department of Sense Organs Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0369-8750","authenticated-orcid":false,"given":"Paola","family":"Andreozzi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Endocrine\u2010Metabolic Sciences and Infectious Diseases  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2306-1888","authenticated-orcid":false,"given":"Lydia Thaleia","family":"Tzigkie","sequence":"additional","affiliation":[{"name":"Department of Sense Organs Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-7820","authenticated-orcid":false,"given":"Marco","family":"de Vincentiis","sequence":"additional","affiliation":[{"name":"Department of Sense Organs Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2030-3534","authenticated-orcid":false,"given":"Diletta","family":"Angeletti","sequence":"additional","affiliation":[{"name":"Department of Sense Organs Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0546-7051","authenticated-orcid":false,"given":"Massimo","family":"Fusconi","sequence":"additional","affiliation":[{"name":"Department of Sense Organs Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP\u20102020\u20100347"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000292"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.03.016"},{"key":"e_1_2_11_5_1","first-page":"325","volume-title":"National Report on Medicines Use in Italy","author":"Magrini N.","year":"2020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1161\/01.ATV.0000190608.28704.71","article-title":"Changes in Ubiquitin Proteasome Pathway Gene Expression in Skeletal Muscle With Exercise and Statins","volume":"25","author":"Urso M. 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