{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:01:43Z","timestamp":1790766103762,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Otolaryngology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize trial design, endpoint emphasis and public results reporting in interventional laryngeal cancer studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Registry\u2010based descriptive study of trial records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>ClinicalTrials.gov; records were retrieved on 28 July 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Interventional trials retrieved using the term \u2018laryngeal cancer\u2019 and with a documented start date between 1988 and 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Trial phase, planned enrolment, design features, intervention strategies, registered endpoint domains, results posting and discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 404 trials. Most were early\u2010to mid\u2010phase with modest enrolment, and masking was recorded in 10.6%. Randomization was documented in 34.7% overall and was more frequent in 2009\u20132025 than in 1988\u20132008. Across three study eras, the proportion of trials specifying survival endpoints increased from 34.2% to 68.4%. Quality\u2010of\u2010life or patient\u2010reported endpoints increased from 11.0% to 36.8%, and swallowing endpoints increased from 6.3% to 17.1%. Voice endpoints remained uncommon (3.8%\u20136.6%), and 21 trials (5.2%) specified an explicit larynx\u2010preservation endpoint. Results were posted for 23.5% of trials, and 16.1% were discontinued.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Registrations increasingly reflect survival and patient\u2010centred priorities, although explicit larynx\u2010preservation endpoints and publicly posted results remain uncommon. Future trials may benefit from larynx\u2010specific designs, consistent assessment of larynx preservation and function with adequate follow\u2010up, and timely dissemination of results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/coa.70174","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:18:58Z","timestamp":1790763538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trial Design, Endpoints and Results Reporting in Interventional Laryngeal Cancer Trials: A Registry\u2010Based Analysis"],"prefix":"10.1111","author":[{"given":"Jin","family":"Wang","sequence":"first","affiliation":[{"name":"Medical College of Jinzhou Medical University  Jinzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8952-0373","authenticated-orcid":false,"given":"Junfeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shanghai Jiading District Anting Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6629-0709","authenticated-orcid":false,"given":"Ziqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical College of Jinzhou Medical University  Jinzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8949-519X","authenticated-orcid":false,"given":"Yihao","family":"Pei","sequence":"additional","affiliation":[{"name":"Medical College of Jinzhou Medical University  Jinzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2144-8034","authenticated-orcid":false,"given":"Fance","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shanghai Jiading District Anting Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Han","sequence":"additional","affiliation":[{"name":"School\/Hospital of Stomatology, Guizhou Medical University  Guiyang China"},{"name":"Basic Medical College, Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000902"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-019-1299-8"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.6097"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1409364"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33220-9"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7036"},{"issue":"5","key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1016\/j.ijrobp.2021.12.138","article-title":"Patient\u2010Reported Outcomes in Head and Neck Cancer: A Systematic Review of Clinical Trials","volume":"112","author":"Cao A. 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