{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:56:58Z","timestamp":1773417418008,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Summary<\/jats:title>Many changes associated with bariatric surgery have the potential to affect warfarin dosing; yet current literature includes little data describing this phenomenon. Investigating this relationship may allow for determination of post\u2010bariatric surgery warfarin dosing using stable pre\u2010operative dosing levels. A retrospective chart review was completed for 10 patients stabilized on chronic warfarin therapy who underwent bariatric surgery. Data collection consisted of the following: warfarin requirement in mg\/week, time in target range (TTR<\/jats:styled-content>), creatinine, liver function, diarrhoea, medication changes, diet, and signs of bleeding and\/or thrombosis. Three study patients underwent laparoscopic adjustable gastric banding procedures and seven patients underwent R<\/jats:styled-content>oux\u2010en\u2010Y<\/jats:styled-content> gastric bypass. The average (standard deviation) weekly warfarin dose required in the immediate post\u2010operative interval was 64% (25%) of baseline dosing, corresponding to a TTR<\/jats:styled-content> of 48%. At 6 months, patients required 85% (19%) of baseline weekly dosing, with TTR<\/jats:styled-content> of 53.4%. At 1 year, dosing was 90% (16%) of baseline with TTR<\/jats:styled-content> of 63.5%. Patients underwent medication changes as well as transient bouts of diarrhoea. Two patients suffered unspecified haemorrhages of the gastrointestinal tract (international normalized ratio [INR<\/jats:styled-content>]\u2009=\u20092.3 and 9.8). This patient set demonstrated an initial drop in warfarin requirement, followed by escalating dosing trends that became more predictable as patients were farther out from procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cob.12046","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T11:00:42Z","timestamp":1392980442000},"page":"108-115","source":"Crossref","is-referenced-by-count":19,"title":["Warfarin dosing after bariatric surgery: a retrospective study of 10 patients previously stable on chronic warfarin therapy"],"prefix":"10.1111","volume":"4","author":[{"given":"A. M.","family":"Schullo\u2010Feulner","sequence":"first","affiliation":[{"name":"Department of Pharmacy Methodist Hospital St. Louis Park MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Stoecker","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hennepin County Medical Center Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Surgery Methodist Hospital St. Louis Park MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Methodist Hospital St. Louis Park MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Surgery Methodist Hospital St. Louis Park MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Burnett","sequence":"additional","affiliation":[{"name":"Department of Anticoagulation Park Nicollet St. Louis Park MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060033"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.12.1537"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1307"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-007-9290-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1381\/096089203322618623"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvn.2006.02.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.229"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1651587"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-081X(199708)18:6<523::AID-BDD39>3.0.CO;2-2"}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcob.12046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.12046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:48:26Z","timestamp":1696351706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.12046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,20]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/cob.12046"],"URL":"https:\/\/doi.org\/10.1111\/cob.12046","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"value":"1758-8103","type":"print"},{"value":"1758-8111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,20]]}}}