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For a given body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), individuals taking <jats:styled-content style=\"fixed-case\">SSRIs<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u2009219) tended to have significantly better health risk profiles with lower systolic blood pressure (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) and higher high\u2010density lipoprotein (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) compared with non\u2010users. Conversely, those who used <jats:styled-content style=\"fixed-case\">TCAs<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u2009116) had significantly worse health risk profiles with higher diastolic blood pressure (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.0001) and triglycerides (<jats:italic>P<\/jats:italic>\u2009=\u20090.023) as compared with non\u2010users for a given <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. Insulin resistance (<jats:styled-content style=\"fixed-case\">HOMA\u2010IR<\/jats:styled-content>) was higher in <jats:styled-content style=\"fixed-case\">TCA<\/jats:styled-content> users and those with larger <jats:styled-content style=\"fixed-case\">BMIs<\/jats:styled-content>, whereby the differences in insulin resistance between <jats:styled-content style=\"fixed-case\">TCA<\/jats:styled-content> users and non\u2010users was greater with higher <jats:styled-content style=\"fixed-case\">BMIs<\/jats:styled-content> (interaction effect: <jats:italic>P<\/jats:italic>\u2009=\u20090.013). Furthermore, individuals taking <jats:styled-content style=\"fixed-case\">SSRIs<\/jats:styled-content> were less likely to have cardiovascular disease than non\u2010users (odds ratio, 95% confidence interval\u2009=\u20090.50, 0.33\u20130.75) for a given <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, with no differences by <jats:styled-content style=\"fixed-case\">TCA<\/jats:styled-content> use (odds ratio\u2009=\u20090.74, 0.44\u20131.24). <jats:styled-content style=\"fixed-case\">SSRI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TCA<\/jats:styled-content> use may alter how body weight relates with cardiovascular risk. When prescribing antidepressant medications, it may be necessary to monitor and consider body weight and cardiovascular risk profile of individual patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cob.12067","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T07:23:23Z","timestamp":1405668203000},"page":"296-302","source":"Crossref","is-referenced-by-count":9,"title":["Tricyclic and <scp>SSRI<\/scp> usage influences the association between <scp>BMI<\/scp> and health risk factors"],"prefix":"10.1111","volume":"4","author":[{"given":"K. J.","family":"Serodio","sequence":"first","affiliation":[{"name":"Faculty of Health School of Kinesiology and Health Science York University  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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