{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:26:26Z","timestamp":1762521986932},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Obesity is associated with lower vitamin D levels compared with normal weight subjects, and if levels are not replaced prior to bariatric surgery, this can increase fracture risk as bone density typically falls post\u2010operatively. We analysed the effect of body mass index (BMI) on vitamin D levels in response to 300 000 IU of colecalciferol in patients with vitamin D deficiency (&lt;30 nmol L<jats:sup>\u22121<\/jats:sup>). Patients were grouped according to their BMI as normal weight (20\u201324.9 kg m<jats:sup>\u22122<\/jats:sup>), overweight (25\u201329.9 kg m<jats:sup>\u22122<\/jats:sup>), obese class I (30\u201334.9 kg m<jats:sup>\u22122<\/jats:sup>) and obese class II and above (&gt;35 kg m<jats:sup>\u22122<\/jats:sup>). The records were retrospectively analysed to investigate the effects of BMI on vitamin D (total 25\u2010hydroxy vitamin D [25(OH)D]), serum Ca<jats:sup>2+<\/jats:sup> and parathyroid hormone (PTH) levels at 6, 12, 26 and 52 weeks compared with baseline. Compared with normal weight subjects, overweight and obese patients achieved lower mean peak total 25(OH)D levels (6 weeks post\u2010loading), which was most significant in the class II and above group (mean total 25(OH)D levels 96.5 \u00b1 24.2 nmol L<jats:sup>\u22121<\/jats:sup> and 72.42 \u00b1 24.9 nmol L<jats:sup>\u22121<\/jats:sup>, respectively; <jats:italic>P<\/jats:italic> = 0.003). By 26 weeks, total 25(OH)D levels fell in all groups; however, there was now a significant difference between the normal weight subjects and all other groups (mean total 25(OH)D levels 84.1 \u00b1 23.7 nmol L<jats:sup>\u22121<\/jats:sup>; 58 \u00b1 20 nmol L<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.0002; 62.65 \u00b1 19.2 nmol L<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.005; 59.2 \u00b1 21 nmol L<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.005, respectively). Far fewer patients in the overweight and obese groups maintained levels above the recommended level of 75 nmol L<jats:sup>\u22121<\/jats:sup> 52 weeks post\u2010loading (93%; 20%, <jats:italic>P<\/jats:italic> = 0.0003; 23%, <jats:italic>P<\/jats:italic> = 0.01; and 14%, <jats:italic>P<\/jats:italic> = 0.001, respectively). Alternative regimes for the treatment of vitamin D deficiency are needed in overweight and obese patients, especially those in whom bariatric surgery is planned.<\/jats:p>","DOI":"10.1111\/cob.12176","type":"journal-article","created":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T14:23:38Z","timestamp":1485959018000},"page":"92-97","source":"Crossref","is-referenced-by-count":10,"title":["High\u2010dose oral colecalciferol loading in obesity: impact of body mass index and its utility prior to bariatric surgery to treat vitamin D deficiency"],"prefix":"10.1111","volume":"7","author":[{"given":"R. J.","family":"King","sequence":"first","affiliation":[{"name":"Department of Endocrinology St. James\u2019 University Hospital  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Chandrajay","sequence":"additional","affiliation":[{"name":"Department of Endocrinology St. James\u2019 University Hospital  Leeds UK"},{"name":"Department of Clinical Biochemistry St. James\u2019 University Hospital  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology St. James\u2019 University Hospital  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Orme","sequence":"additional","affiliation":[{"name":"Department of Endocrinology St. James\u2019 University Hospital  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Barth","sequence":"additional","affiliation":[{"name":"Department of Endocrinology St. James\u2019 University Hospital  Leeds UK"},{"name":"Department of Clinical Biochemistry St. James\u2019 University Hospital  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e5085"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12145"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-015-1724-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.690"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-007-9315-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.120139"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.328"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2012.12.003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-013-0634-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21150"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2707"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3574-y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4103"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5030949"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.404"},{"key":"e_1_2_9_20_1","article-title":"Discordance between fat mass index and body mass index is associated with reduced bone mineral density in women but not in men: the Busselton Healthy Ageing Study","volume":"28","author":"Zhu K","year":"2016","journal-title":"Osteoporos Int"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-012-0104-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1656"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1466"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.06.013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.08.018"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.594"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem240"}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcob.12176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.12176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T13:11:56Z","timestamp":1696252316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.12176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/cob.12176"],"URL":"https:\/\/doi.org\/10.1111\/cob.12176","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"value":"1758-8103","type":"print"},{"value":"1758-8111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]}}}