{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:12:16Z","timestamp":1780384336513,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Heart & Stroke Ontario Graduate Scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Summary<\/jats:title>The aortic pulse wave velocity (PWV<\/jats:styled-content>) measured via cardiac magnetic resonance (CMR<\/jats:styled-content>) can be used to non\u2010invasively assess changes in arterial stiffness and potential underlying vascular dysfunction. This technique could unmask early arterial dysfunction in overweight and obese youth at risk for cardiovascular disease. We sought to determine the association between vascular stiffness, percentage body fat, body mass index (BMI<\/jats:styled-content>), and cardiac function in adolescents across the weight spectrum through both CMR<\/jats:styled-content> and standard applanation tonometry (AT<\/jats:styled-content>)\u2010based PWV<\/jats:styled-content> measurements. PWV<\/jats:styled-content> and left\u2010ventricular cardiac function were assessed using 3.0 T CMR<\/jats:styled-content> in obese and overweight (OB<\/jats:styled-content>\/OW<\/jats:styled-content>) participants (n<\/jats:italic> = 12) and controls (n<\/jats:italic> = 7). PWV<\/jats:styled-content> was also estimated via carotid\u2013femoral AT<\/jats:styled-content>. OB<\/jats:styled-content>\/OW<\/jats:styled-content> participants did not differ from healthy\u2010weight controls regarding cardiometabolic risk factors or physical activity levels, but there was a trend towards higher levels of triglycerides in obese\/overweight participants (P<\/jats:italic> = 0.07). Mean PWV<\/jats:styled-content> was higher in obese participants when corrected for age and sex (P<\/jats:italic> = 0.01), and was positively associated with BMI<\/jats:styled-content> (\u03b2<\/jats:italic> = 0.51, P<\/jats:italic> = 0.02). PWV<\/jats:styled-content> estimated through AT<\/jats:styled-content> was not significantly different between groups. Cardiac function measured by left\u2010ventricular ejection fraction z<\/jats:italic>\u2010score was inversely associated with mean PWV<\/jats:styled-content> (\u03b2<\/jats:italic> = \u22120.57, P<\/jats:italic> = 0.026). Increasing arterial stiffness and decreasing cardiac function were evident among our overweight and obese cohort. PWV<\/jats:styled-content> estimated by CMR<\/jats:styled-content> could detect early increases in arterial stiffness vs. traditional AT<\/jats:styled-content> measurements of PWV<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cob.12206","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T06:52:43Z","timestamp":1503471163000},"page":"360-367","source":"Crossref","is-referenced-by-count":12,"title":["Magnetic resonance imaging reveals elevated aortic pulse wave velocity in obese and overweight adolescents"],"prefix":"10.1111","volume":"7","author":[{"given":"J. E.","family":"Caterini","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology and Physical Education University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Banks","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Physical Education University of Toronto Toronto Canada"},{"name":"Labatt Family Heart Centre Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. D.","family":"Wells","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Physical Education University of Toronto Toronto Canada"},{"name":"Translational Medicine Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cifra","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Centre Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Slorach","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Centre Hospital for Sick Children Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W.","family":"McCrindle","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Centre Hospital for Sick Children Toronto Canada"},{"name":"Department of Pediatrics, Faculty of Medicine University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Seed","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Centre Hospital for Sick Children Toronto Canada"},{"name":"Department of Pediatrics, Faculty of Medicine University of Toronto Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211053271904"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90726-F"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705283162204"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.272"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32830a4a25"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl254"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22570"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-12-26"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833a6132"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.123364"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.12.018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306561"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.64"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.133645"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.1.45"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199512000-00017"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199805000-00021"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10262"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.555235"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-77"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.1.50"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.532663"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.zhq0504.0173"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-543X.2006.00139.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl163"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06525-4"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.030"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.065"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev332"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.632"}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcob.12206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.12206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:55:27Z","timestamp":1695992127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.12206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/cob.12206"],"URL":"https:\/\/doi.org\/10.1111\/cob.12206","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"value":"1758-8103","type":"print"},{"value":"1758-8111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,23]]}}}