{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:28:48Z","timestamp":1753878528247,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Madelung's disease is characterized by the manifestation of multiple ectopic lipomas, usually found in the cervical\u2010thoracic region, however, clinical manifestation may vary among patients. It has been postulated that lipomas associated with Madelung's disease are linked to brown adipose tissue (BAT) due to the presence of uncoupling protein 1 (UCP1). Therefore, we here investigated whether BAT activity is present in a patient with Madelung's disease. <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) uptake using PET\/CT after a cooling procedure was measured together with body temperature and energy expenditure. Finally, adipose tissue biopsies were taken from the lipomas for gene expression analysis and histology. <jats:sup>18<\/jats:sup>F\u2010FDG uptake was not detected after the cooling procedure in the lipomas. Furthermore, adipose tissue biopsies derived from the lipomas did not express UCP1. We thus conclude that cold\u2010stimulated BAT activity was not detected in lipomas associated with Madelung's disease. Additional research in other patients is needed to unravel the role of dysfunctional BAT in Madelung's disease.<\/jats:p>","DOI":"10.1111\/cob.12302","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T07:45:56Z","timestamp":1551339956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Absence of <sup>18<\/sup>F\u2010fluorodeoxyglucose uptake using Positron Emission Tomography\/Computed Tomography in Madelung's disease: A case report"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8207-3953","authenticated-orcid":false,"given":"Michiel P.B.","family":"Moonen","sequence":"first","affiliation":[{"name":"Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translation Research in Metabolism Maastricht University  Maastricht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmani B.M.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translation Research in Metabolism Maastricht University  Maastricht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinus J.P.G.","family":"van Kroonenburgh","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Maastricht University Medical Center  Maastricht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dees","family":"Brandjes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Slotervaart Medical Centre  Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter D.","family":"van Marken Lichtenbelt","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translation Research in Metabolism Maastricht University  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