{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:36:38Z","timestamp":1780054598361,"version":"3.54.0"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Two cases of middle\u2010aged female patients treated by gastric bypass surgery for weight loss presented to our clinic for a follow\u2010up examination 3\u20106 months after the surgical procedure (a mini gastric bypass and a modified single anastomosis sleeve\u2010ileostomy). In both patients increased ACTH levels and either high serum cortisol or an increased urinary cortisol excretion was apparent and triggered further endocrine testing. Serum cortisol could not be suppressed adequately by 2 and 4 mg dexamethasone in the standardized oral overnight suppression test while midnight salivary cortisol dropped well below the desired cut\u2010off. This led to the hypothesis of an impaired dexamethasone resorption and could be further substantiated by suppression of serum cortisol below the cut\u2010off by an intravenous dexamethasone application. The data presented point to an impairment of enteral synthetic corticosteroid resorption in patients after gastric bypass surgery and could be of importance for individuals in need for immunosuppressive treatment. In view of the growing number of bariatric procedures, pharmacokinetics of corticosteroids and other drugs should be tested in clinical trials.<\/jats:p>","DOI":"10.1111\/cob.12383","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T01:53:00Z","timestamp":1592013180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impaired dexamethasone resorption in two patients with <scp>pseudo\u2010Cushing<\/scp> after bariatric surgery: Implications for immunosuppressive treatment"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-977X","authenticated-orcid":false,"given":"Per M.","family":"Humpert","sequence":"first","affiliation":[{"name":"Stoffwechselzentrum Rhein\u2010Pfalz  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azat","family":"Samigullin","sequence":"additional","affiliation":[{"name":"Stoffwechselzentrum Rhein\u2010Pfalz  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of General and Bariatric Surgery, Diakonissenkrankenhaus Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Weihrauch","sequence":"additional","affiliation":[{"name":"Stoffwechselzentrum Rhein\u2010Pfalz  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Oikonomou","sequence":"additional","affiliation":[{"name":"Stoffwechselzentrum Rhein\u2010Pfalz  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Metzner","sequence":"additional","affiliation":[{"name":"Stoffwechselzentrum Rhein\u2010Pfalz  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut A.","family":"B\u00f6ttcher","sequence":"additional","affiliation":[{"name":"Department of General and Bariatric Surgery, Diakonissenkrankenhaus Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Morcos","sequence":"additional","affiliation":[{"name":"Stoffwechselzentrum Rhein\u2010Pfalz  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Siemens Healthcare Diagnostics Products Ltd. IMMULITE\u00ae2000ACTH assay technical manual (PIL2KAC\u201018 2018\u201003\u201015) 2018."},{"key":"e_1_2_5_3_1","unstructured":"Siemens Healthcare Diagnostics Inc.. ADVIA Centaur\u00ae Cortisol Immunoassay technical manual (10994987_EN Rev D 2019\u201003).2019."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030871"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2016.12.018"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12988"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544010-00003"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01059447"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-25-10-1309"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-019-03925-1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13232"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/JC.2015-2078"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2019-00027"},{"key":"e_1_2_5_14_1","unstructured":"American Society for Metabolic and Bariatric Surgery. Estimate of Bariatric Surgery Numbers 2011\u20102018. Online2018."}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcob.12383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.12383","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cob.12383","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.12383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T06:31:06Z","timestamp":1693895466000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.12383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,12]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/cob.12383"],"URL":"https:\/\/doi.org\/10.1111\/cob.12383","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"value":"1758-8103","type":"print"},{"value":"1758-8111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,12]]},"assertion":[{"value":"2020-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12383"}}