{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:08:24Z","timestamp":1785888504228,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To retrospectively review the efficacy of short term supervised medical weight loss for women with obesity, body mass index (BMI \u226540\u2009kg\/m<jats:sup>2<\/jats:sup>) in gynaecologic oncology, and the associated perioperative and pathologic outcomes. A retrospective study of a dedicated preoperative weight loss clinic for gynaecologic oncology patients from March to December 2019. Statistical analysis was performed with McNemar's test for correlated proportions, Pearson's correlation tests for continuous variables, and paired <jats:italic>t<\/jats:italic>\u2010tests to compare means. Generalized estimating equations (GEE) were used to determine the factors associated with weight loss over time. A <jats:italic>P<\/jats:italic>\u2010value of &lt;.05 was used for statistical significance. Review of cases up\u2010graded after surgery was performed by a gynaecologic pathologist. There were a total of 49 women included in the study. The most common referral reason was endometrioid carcinoma or hyperplasia of the endometrium (77.6%). Mean initial weight was 130.2 kg, and corresponding mean BMI 48.1 kg\/m<jats:sup>2<\/jats:sup>. Patients attended on average nine preoperative weight loss visits. A significant difference between initial weight and weight at surgery was demonstrated, from 129.6 to 118.0 kg (8.4% weight loss) (<jats:italic>P\u2009&lt;<\/jats:italic> .0001). This difference persisted to their post\u2010surgical visit, with an additional mean loss of 1.89\u2009kg (9.4% weight loss) (<jats:italic>P\u2009=<\/jats:italic> .044). The majority (92.1%) of patients with endometrial pathology had surgical management, and of these 85.7% were minimally invasive. Preoperative weight loss is a feasible option in gynaecologic oncology patients. Greater understanding of clinical significance, follow\u2010up, and ideal target population for this intervention is needed.<\/jats:p>","DOI":"10.1111\/cob.12445","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T11:19:57Z","timestamp":1615547997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preoperative weight loss in women with obesity in gynaecologic oncology: A retrospective study"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0054-808X","authenticated-orcid":false,"given":"Christa","family":"Aubrey","sequence":"first","affiliation":[{"name":"Gynecologic Oncology Fellow, Tom Baker Cancer Centre, Department of Oncology University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Skeldon","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Chapelsky","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Giannakopoulos","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Research Scientist, Alberta Health Services\u2010Cancer Control Alberta, Department of Medical Oncology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Steed","sequence":"additional","affiliation":[{"name":"Cross Cancer Institute, Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Pin","sequence":"additional","affiliation":[{"name":"Cross Cancer Institute, Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"issue":"88","key":"e_1_2_8_2_1","article-title":"The incidence of co\u2010morbidites related to obesity and overweight: a systematic review and meta\u2010analysis","volume":"9","author":"Guh DP","year":"2009","journal-title":"BMC Public Health"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60269-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0832"},{"issue":"9612","key":"e_1_2_8_5_1","first-page":"569","article-title":"Body\u2010mass index and 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