{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:06:50Z","timestamp":1773788810654,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>There have been increased reports of orthostatic intolerance post\u2010bariatric surgery. However, the prevalence, pathophysiology and long\u2010term outcomes have not been well described. Therefore, we sought to summarize evidence of orthostatic intolerance after bariatric surgery. We conducted a systematic review using PubMed, Scopus, CINAHL, Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials (CENTRAL) to identify relevant articles from the date of inception until 1st April 2020. Study selection, data extraction and quality assessment of the included studies were performed independently by two reviewers. The findings of the included studies were narratively reported. When feasible, a meta\u2010analysis was done to summarize the relevant results. We included 20 studies (<jats:italic>n<\/jats:italic>\u00a0=\u200919\u2009843 participants) reporting findings of 12 prospective cohort studies, 5 retrospective cohort studies, 2 cross\u2010sectional studies and one randomized controlled trial. The 5\u2010year cumulative incidence of orthostatic intolerance was 4.2% (one study). Common clinical presentations of orthostatic intolerance were lightheadedness, dizziness, syncope and palpitation. The pooled data suggested improvement in overall cardiac autonomic function (sympathetic and parasympathetic) post\u2010bariatric surgery. In addition, a significant systolic blood pressure drop may reflect a reset of the balance between the sympathetic and parasympathetic nervous systems after weight loss in the pooled analysis. Existing literature on orthostatic intolerance post\u2010bariatric surgeries was limited or of low quality, and larger studies are needed to know the true incidence of orthostatic intolerance post\u2010bariatric surgeries and the pathophysiology. We found one study reporting the 5\u2010years cumulative incidence of orthostatic intolerance post\u2010bariatric surgeries as only 4.2%. This could challenge the idea of increased orthostatic intolerance prevalence post\u2010bariatric surgeries. Registration The review protocol was registered at the International Prospective Register of Systemic Reviews PROSPERO (CRD42020170877).<\/jats:p>","DOI":"10.1111\/cob.12483","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T08:41:11Z","timestamp":1629362471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Orthostatic intolerance after bariatric surgery: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"11","author":[{"given":"Jawahar","family":"Al Nou'mani","sequence":"first","affiliation":[{"name":"Oman Medical Specialty Board  Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-7186","authenticated-orcid":false,"given":"Abdullah M.","family":"Al Alawi","sequence":"additional","affiliation":[{"name":"Oman Medical Specialty Board  Muscat Oman"},{"name":"Department of Medicine Sultan Qaboos 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