{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:47:07Z","timestamp":1793227627618,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To evaluate the effect of dietary interventions aimed at weight loss in gastroesophageal reflux disease (GERD) symptoms and general health\u2010related quality of life (HRQL) in overweight and obese patients. A population of GERD patients were randomized into two groups: the intervention group received individualized dietary counselling on scheduled appointments throughout 6\u00a0months of follow\u2010up (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) and the control group received only informative dietary guidelines on baseline (<jats:italic>n<\/jats:italic>\u00a0=\u00a031). Anthropometric data were monthly collected, and the HRQL score for GERD (GERD\u2010HRQL) and the Health Survey (SF\u201036) questionnaires were applied on baseline and reevaluated at the end of follow\u2010up. Dietary intervention led to an average weight loss of 4.4\u00a0kg (\u00b15.3) and an average BMI reduction of 1.7\u00a0kg\/m<jats:sup>2<\/jats:sup> (\u00b12.9) compared to an increase in weight of 2.1\u00a0kg (\u00b14.4) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and an increase in BMI of 1.3 (\u00b16.3) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.023) in the control group. Individuals in the intervention group had a mean decrease in symptoms of 6.8 (\u00b15.5) points while the control group had worsening of their symptoms with an increase of 3.3 (\u00b14) points (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) in the disease\u2010specific questionnaire. There was a positive association between weight loss and reduction of symptoms as measured by the GERD\u2010HRQL score (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.49; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Dietary intervention for 6\u00a0months with an individualized low\u2010calorie diet program produces weight loss and a significant improvement in GERD\u2010related symptoms, as well as in HRQL.<\/jats:p>","DOI":"10.1111\/cob.12556","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T04:23:33Z","timestamp":1663993413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Dietary weight loss intervention provides improvement of gastroesophageal reflux disease symptoms\u2014A randomized clinical trial"],"prefix":"10.1111","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-0429","authenticated-orcid":false,"suffix":"Jr","given":"Dirceu Felipe","family":"Valentini","sequence":"first","affiliation":[{"name":"Medicine: Surgical Sciences, Medical School of Universidade Federal do Rio Grande do Sul (FAMED\u2010UFRGS)  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daieni","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Medical School of Universidade Federal do Rio Grande do Sul (FAMED\u2010UFRGS)  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Jardim","family":"Campos","sequence":"additional","affiliation":[{"name":"Medicine: Surgical Sciences, Medical School of Universidade Federal do Rio Grande do Sul (FAMED\u2010UFRGS)  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Silva","family":"Mazzini","sequence":"additional","affiliation":[{"name":"Service of Digestive Surgery, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Gurski","sequence":"additional","affiliation":[{"name":"Medicine: Surgical Sciences, Medical School of Universidade Federal do Rio Grande do Sul (FAMED\u2010UFRGS)  Porto Alegre Rio Grande do Sul Brazil"},{"name":"Gastroenterology and Hepatology, Medical School of Universidade Federal do Rio Grande do Sul (FAMED\u2010UFRGS)  Porto Alegre Rio Grande do Sul Brazil"},{"name":"Service of Digestive Surgery, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.045"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010313589"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00354-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2011.04774.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03428.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401101"},{"key":"e_1_2_6_10_1","unstructured":"World Health Organization.Obesity and overweight. 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