{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:26:24Z","timestamp":1783607184161,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Anti\u2010M\u00fcllerian hormone (AMH) is commonly used as a marker of ovarian reserve. Although obesity is associated with decreased fertility, the relationship between body mass index (BMI) and AMH remains uncertain, hindering the accurate interpretation of AMH. We sought to assess the relationship between serum AMH and BMI in patients with and without polycystic ovarian syndrome (PCOS). This study analysed 500 patients at a single centre between 2020 and 2021. Patients were divided into cohorts: those with BMI &lt;40\u2009kg\/m<jats:sup>2<\/jats:sup> and those with BMI &gt;40\u2009kg\/m<jats:sup>2<\/jats:sup>. Patients with and without PCOS were included. Chi\u2010square tests, Fisher's exact tests, multiple linear regression analysis and independent <jats:italic>t<\/jats:italic>\u2010tests were performed as appropriate. In the general study population, serum AMH was not significantly different in the BMI &gt;40\u2009kg\/m<jats:sup>2<\/jats:sup> group compared to the BMI &lt;40\u2009kg\/m<jats:sup>2<\/jats:sup> group (4.3\u2009\u00b1\u20095.6 vs. 4.3\u2009\u00b1\u20095.6, <jats:italic>p<\/jats:italic>\u2009=\u2009.35). Patient ages between these two groups differed, with an average age of 35.4\u2009\u00b1\u20095.4\u2009years in the BMI &lt;40\u2009kg\/m<jats:sup>2<\/jats:sup> group and 33.7\u2009\u00b1\u20095.4\u2009years in the BMI &lt;40\u2009kg\/m<jats:sup>2<\/jats:sup> group (<jats:italic>p<\/jats:italic>\u2009=\u2009.031). Our multivariate regression analysis, which adjusted for age, demonstrated a significant interaction effect between BMI and PCOS diagnosis, indicating that the relationship between BMI and AMH is dependent on PCOS status (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u2212.03, 95% confidence interval [CI]: \u22120.05, 0.00, <jats:italic>p<\/jats:italic>\u2009=\u2009.044). In patients without PCOS, we found a non\u2010significant relationship between AMH and BMI (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.00, 95% CI \u22120.01, 0.01, <jats:italic>p<\/jats:italic>\u2009=\u2009.7); however, in patients with PCOS, AMH significantly decreased as BMI increased (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u2212.03, 95% CI \u22120.06, 0.00, <jats:italic>p<\/jats:italic>\u2009=\u2009.034). BMI has an inverse association with AMH levels in patients with PCOS, indicating a need for future research to determine if that interaction represents a clinically significant negative effect on reproductive function.<\/jats:p>","DOI":"10.1111\/cob.12638","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T10:03:46Z","timestamp":1703844226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Increased body mass index is negatively associated with ovarian reserve as measured by anti\u2010M\u00fcllerian hormone in patients with polycystic ovarian syndrome"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9196-7887","authenticated-orcid":false,"given":"Jacqueline","family":"Kloos","sequence":"first","affiliation":[{"name":"Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Perez","sequence":"additional","affiliation":[{"name":"Clinical Research Center, University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Weinerman","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.05.040"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep210"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010019\u20100497\u20104"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006\u20101582"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.03.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey256"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep360"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.06.010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010016\u20102528\u2010y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0193945918792303"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.05.013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404\u2010012\u20102363\u2010x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.05.051"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010018\u20101555\u2010y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21681"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa436"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010015\u20100538\u20107"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13098"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12687"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.10.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010015\u20100540\u20100"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.03.007"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12559"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2016.1169267"},{"key":"e_1_2_9_27_1","volume-title":"R: 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