{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:29:53Z","timestamp":1790562593433,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Hypothalamic obesity does not respond well to conventional interventions for obesity. GLP\u20101 receptor agonists have mechanisms independent of the hypothalamus which may be potentially beneficial for managing hypothalamic obesity. This systematic review summarizes the efficacy and safety of GLP\u20101 receptor agonists use in hypothalamic obesity. A PRISMA\u2010compliant systematic review was performed. Data was extracted from included studies and analysed based on change in weight, body mass index, glycaemic control, satiety, and safety profile with GLP\u20101 receptor agonist use. Ten studies comprising 5 case reports, 4 case series and 1 randomized\u2010controlled trial included 54 patients (24 males, 30 females) with mean age of 25.2 (range 13\u201371) years with hypothalamic obesity who had received GLP\u20101 receptor agonists (exenatide\u2009=\u200948, liraglutide\u2009=\u20095 and dulaglutide\u2009=\u20091) over a mean duration of treatment of 12 (range 3\u201351) months. Mean weight reduction of 7.4 (SD 7.92) kg was observed in patients in whom weight was reported, with 85.7% of patients experiencing weight loss. All patients on liraglutide had weight reduction post\u2010therapy. The sole trial had reported a non\u2010significant reduction in BMI post\u2010exenatide. Glycaemic control had either improved\/maintained in all patients in whom this was measured. The main side effects of GLP\u20101 receptor agonist in individuals with hypothalamic obesity were nausea and vomiting; there were no major safety concerns. Based on limited published experience, GLP\u20101RA may be effective and safe for weight control in hypothalamic obesity, with the added benefit of improved glycaemic control in those with concurrent diabetes mellitus.<\/jats:p>","DOI":"10.1111\/cob.12642","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T23:09:45Z","timestamp":1706224185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The role of glucagon\u2010like peptide 1 receptor agonists for weight control in individuals with acquired hypothalamic obesity\u2014A systematic review"],"prefix":"10.1111","volume":"14","author":[{"given":"Victoria Wen Wei","family":"Ng","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gheslynn","family":"Gerard","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Jin Kai","family":"Koh","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah Yin","family":"Loke","sequence":"additional","affiliation":[{"name":"Khoo Teck Puat \u2013 National University Children's Medical Institute, Department of Paediatrics National University Hospital  Singapore Singapore"},{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Seng","family":"Lee","sequence":"additional","affiliation":[{"name":"Khoo Teck Puat \u2013 National University Children's Medical Institute, Department of Paediatrics National University Hospital  Singapore Singapore"},{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-8891","authenticated-orcid":false,"given":"Nicholas Beng Hui","family":"Ng","sequence":"additional","affiliation":[{"name":"Khoo Teck Puat \u2013 National University Children's Medical Institute, Department of Paediatrics National University Hospital  Singapore Singapore"},{"name":"Department of Paediatrics, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02231.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-012-0401-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-008-0096-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-832339"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2012.01004.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.ra.2015-0099"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0145-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20646"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.06.121"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916038"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14583"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v7.i20.572"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.8.15.2593"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.31982"},{"key":"e_1_2_8_16_1","unstructured":"Novo Nordisk.FDA Approves Saxenda\u00ae for the Treatment of Obesity in Adolescents Aged 12\u201317. 2020. 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