{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:18:15Z","timestamp":1773051495471,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We aimed to assess the extent to which people with type 2 diabetes or pre\u2010diabetes, obesity (BMI 30\u201345\u2009kg\/m<jats:sup>2<\/jats:sup>) and moderate obstructive sleep apnoea (OSA) requiring continuous positive airway pressure ventilation (CPAP) were able to discontinue CPAP following EndoBarrier\u2010related weight loss. We assessed sleep and metabolic parameters before, during and after EndoBarrier in 12 participants with moderate OSA requiring CPAP (75% female, 8\/12 [66%] type 2 diabetes, 4\/12 [34%] prediabetes, mean\u2009\u00b1\u2009SD age 52.6\u2009\u00b1\u20099.7\u2009years, BMI 37.4\u2009\u00b1\u20093.5\u2009kg\/m<jats:sup>2<\/jats:sup>, median duration of OSA while on CPAP 9.0 [7.0\u201315.0] months). With EndoBarrier in\u2010situ, mean\u2009\u00b1\u2009SD Apnoea Hypopnoea Index (AHI) fell by 9.1\u2009\u00b1\u20095.0\u2009events\/h from 18.9\u2009\u00b1\u20093.8 to 9.7\u2009\u00b1\u20093.0\u2009events\/h (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) with an associated reduction in symptoms of daytime sleepiness (mean Epworth Sleepiness Score) such that all the 12 participants no longer required CPAP according to National Institute for Health and Care Excellence criteria. After EndoBarrier removal, 10\/12 (83%) patients attended follow\u2010up and at 12\u2009months after removal, AHI remained below 15 in 5\/10 (50%) patients but in other five the AHI rose above 15 such that restarting CPAP was recommended as justified by their symptoms. Rather than restart CPAP, two patients lost the regained weight and their AHI dropped below 15 again. Thus, 7\/10 (70%) of patients were able to remain off CPAP 12 or more months after EndoBarrier removal. These results demonstrate major benefit of EndoBarrier in moderate OSA, allowing all patients to discontinue CPAP during treatment, and with maintenance of improvement at follow\u2010up in 70%. They confirm previously demonstrated metabolic improvements in diabetes and obesity.<\/jats:p>","DOI":"10.1111\/cob.12694","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T02:53:55Z","timestamp":1723431235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endoscopic duodenal\u2010jejunal bypass liner treatment of moderate obstructive sleep apnoea\u2014A pilot study"],"prefix":"10.1111","volume":"14","author":[{"given":"Mahender","family":"Yadagiri","sequence":"first","affiliation":[{"name":"Diabetes Department Sandwell &amp; West Birmingham NHS Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona Y.","family":"Kinney","sequence":"additional","affiliation":[{"name":"Research and Development Sandwell &amp; West Birmingham NHS Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Ashman","sequence":"additional","affiliation":[{"name":"Respiratory Physiology Sandwell &amp; West Birmingham NHS Trust, City Hospital  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Bleasdale","sequence":"additional","affiliation":[{"name":"Anaesthetics Department Sandwell &amp; West Birmingham NHS Trust, City Hospital  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward N.","family":"Fogden","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Sandwell &amp; West Birmingham NHS Trust, City Hospital  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark R.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Sandwell &amp; West Birmingham NHS Trust, City Hospital  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Walton","sequence":"additional","affiliation":[{"name":"Diabetes Department Hull Royal Infirmary  Hull UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Greenstone","sequence":"additional","affiliation":[{"name":"Respiratory Department Castle Hill Hospital  Cottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4424-355X","authenticated-orcid":false,"given":"Robert E. 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