{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:28:12Z","timestamp":1753878492831,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSSSP\/0026\/2017\u201000","NMRC\/CSSSP\/0034\/2017\u201000"],"award-info":[{"award-number":["NMRC\/CSSSP\/0026\/2017\u201000","NMRC\/CSSSP\/0034\/2017\u201000"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["H18\/01\/a0\/017"],"award-info":[{"award-number":["H18\/01\/a0\/017"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The relationship between ethnicity, obesity and health\u2010related quality of life outcomes in a multi\u2010ethnic population remains poorly understood. We aim to investigate the relationship between ethnicity, body mass index (BMI), obesity\u2010associated diseases, as well as determinants of quality of life (QoL) in Southeast Asian patients with obesity. We aim to develop and validate a simple objective score to identify patients with obesity at high risk for major depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Associations between ethnicity, obesity\u2010associated diseases, BMI and determinants of QoL (Patient Health Questionnaire\u20109 and 36\u2010Item Short Form Survey) were analysed using multivariate logistic regression in a prospective cohort of 1501 patients with obesity. Multivariate regression and receiver operating characteristics curves were used to develop and validate a novel scoring system to identify patients at risk of major depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients of Chinese, Malay and Indian ethnicity had increased risk of hypertension (odds ratio [OR]: 1.51 [95% confidence interval [CI]: 1.19\u20131.92, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001]), BMI Class 4 (OR: 17.89 [95% CI: 9.53\u201333.60, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001]) and major depression (OR: 1.71 [95% CI: 1.23\u20132.39, <jats:italic>p<\/jats:italic>\u2009=\u2009.002]), respectively. Factors associated with major depression (gender, ethnicity, age, obstructive sleep apnoea, Physical Component Score and Mental Component Score scores) were used to create and validate a novel scoring system with an area under curve of 0.812 (95% CI: 0.787\u20130.837). A cutoff of 4 of 7 points was identified with a sensitivity of 70%, specificity of 81%, positive predictive of 53% and negative predictive value of 90%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of metabolic complications from obesity significantly varies with ethnicity. We developed a novel and simple scoring tool combining objective demographic and patient\u2010reported outcomes to screen and triage patients at risk of major depression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cob.12707","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T02:19:42Z","timestamp":1730341182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determinants of quality of life and emotional well\u2010being in a bariatric surgery seeking cohort of 1501 multi\u2010ethnic Asian patients"],"prefix":"10.1111","volume":"15","author":[{"given":"Wei Yu","family":"Chua","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryl Kai Ann","family":"Chia","sequence":"additional","affiliation":[{"name":"Department of Surgery National 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