{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:58:23Z","timestamp":1781305103216,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["2018.612"],"award-info":[{"award-number":["2018.612"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To evaluate the relationship between serum gamma\u2010glutamyl transferase (GGT) levels and fatty pancreas in subjects with concurrent obesity, insulin resistance and metabolic dysfunction\u2010associated steatotic liver disease (MASLD) without a history of pancreatitis. From March 2019 to September 2021, 31 adult subjects with concurrent obesity and MASLD were recruited as part of the study investigating the biological impact of bariatric surgery and lifestyle modification on obesity. Chemical shift encoded MRI of the abdomen, LiverMultiScan, anthropometric, clinical and blood biochemistry analyses were performed prior to any intervention at baseline. GGT (<jats:italic>p<\/jats:italic>\u2009&lt;.001) was significantly different between those \u2018with fatty pancreas\u2019 and \u2018without fatty pancreas\u2019 groups. GGT (<jats:italic>p<\/jats:italic>\u2009&lt;.001) was significantly different between those \u2018with both metabolic syndrome and fatty pancreas\u2019 and those \u2018with metabolic syndrome but without fatty pancreas.\u2019 GGT (<jats:italic>p<\/jats:italic>\u2009&lt;.001) was also significantly different between those \u2018with both diabetes and fatty pancreas\u2019 and those \u2018with diabetes but without fatty pancreas\u2019. Logistic regression analysis showed that abnormal GGT levels (<jats:italic>p<\/jats:italic>\u2009=\u2009.010) and Hypertension (<jats:italic>p<\/jats:italic>\u2009=\u2009.045) were significant independent predictors of fatty pancreas. GGT was associated with fatty pancreas by an odds ratio 7.333 (95% [CI]: 1.467\u201336.664), while the AUROC of GGT in determining fatty pancreas was 0.849. Elevation in serum GGT might be a potential marker to identify fatty pancreas.<\/jats:p>","DOI":"10.1111\/cob.12712","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T12:35:48Z","timestamp":1729600548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gamma\u2010glutamyl transferase: A potential biomarker for pancreas steatosis in patients with concurrent obesity, insulin resistance and metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-1714","authenticated-orcid":false,"given":"Chileka","family":"Chiyanika","sequence":"first","affiliation":[{"name":"Department of Health Technology and Informatics The Hong Kong Polytechnic University  Hong Kong China"},{"name":"Department of Imaging and Interventional Radiology, Prince of Wales Hospital The Chinese University of Hong Kong  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