{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:28:23Z","timestamp":1764152903652,"version":"3.46.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>This study addresses the diagnostic challenges of identifying lymphoedema in patients with lipoedema using lymphoscintigraphy. Overdiagnosis of lymphoedema in this patient population is frequent and may result in reduced proposed surgical interventions. We retrospectively analyzed clinical data from patients followed for lipoedema, lymphoedema or lipolymphoedema and who underwent lymphoscintigraphy. All patients were assigned a clinical or lymphoscintigraphic diagnosis of lymphoedema and concordance between clinical and lymphoscintigraphic diagnosis was assessed. A modification of lymphoscintigraphic criteria interpretation was proposed to enhance the diagnosis specificity. We included 94 female patients (188 lower limbs). One hundred and thirty\u2010seven limbs presented with signs of lipoedema (137\/188; 72.9%) and 42 with clinical signs of lymphoedema (42\/188; 22.3%). Overall, 125 limbs presented with a diagnosis of lymphoedema on lymphoscintigraphy (125\/188; 66.5%). Using lymphoscintigraphy to diagnose lymphoedema in patients with lipoedema resulted in low specificity (38.3%). By adjusting the interpretation criteria of the lymphoscintigraphic anomalies, we could achieve a specificity of 80.85%, reducing the risk of overdiagnosing lymphoedema in patients with lipoedema. This study contributes to the ongoing efforts to optimize the assessment and management of patients with lipoedema and potential lymphatic involvement, by modifying the interpretation of lymphoscintigraphic criteria.<\/jats:p>","DOI":"10.1111\/cob.12730","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T07:25:41Z","timestamp":1734679541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing lymphoscintigraphic specificity of lymphoedema diagnosis in patients with lipoedema"],"prefix":"10.1111","volume":"15","author":[{"given":"Hadrien","family":"Amiel","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, CHU UCL Namur (Site Sainte Elisabeth) Universit\u00e9 Catholique de Louvain  Namur Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Coulie","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Esthetic Surgery, Cliniques Universitaires Saint\u2010Luc UCLouvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00ebl","family":"Georis","sequence":"additional","affiliation":[{"name":"Scientific Support Unit, CHU UCL Namur (Site Godinne) UCLouvain  Namur Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8028-8651","authenticated-orcid":false,"given":"Raquel","family":"van la Parra","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, CHU UCL Namur (Site Sainte Elisabeth) Universit\u00e9 Catholique de Louvain  Namur Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevieve","family":"Pirson","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, CHU UCL Namur (Site Sainte Elisabeth) Universit\u00e9 Catholique de Louvain  Namur Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Deconinck","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, CHU UCL Namur (Site Sainte Elisabeth) Universit\u00e9 Catholique de Louvain  Namur Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2023.05.056"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22597"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126621"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734614554284"},{"key":"e_1_2_9_6_1","first-page":"396","article-title":"Lipedema\u2014Pathogenesis, diagnosis, and treatment options","volume":"117","author":"Kruppa P","year":"2020","journal-title":"Dtsch \u00c4rztebl Int"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13648"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"1","article-title":"Lipedema fat and signs and symptoms of illness, increase with advancing stage","volume":"7","author":"Herbst KL","year":"2015","journal-title":"Arch Med"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23458"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","unstructured":"Current Concepts in the Surgical Management of Lymphedema. Vol. 139.2017.","DOI":"10.1097\/PRS.0000000000003218"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1758-8111.2012.00045.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000244909.82805.dc"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/7140.2006.00006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12820"},{"key":"e_1_2_9_15_1","article-title":"Debulking surgery for elephantiasis nostras with large ectatic podoplanin\u2010negative lymphatic vessels in patients with lipo\u2010lymphedema","volume":"14","author":"Wollina U","year":"2014","journal-title":"Eplasty"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-9590.21.04604-6"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25526"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001396"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0398-0499(04)96770-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mednuc.2010.10.008"},{"issue":"1","key":"e_1_2_9_21_1","first-page":"43","article-title":"The third circulation: radionuclide lymphoscintigraphy in the evaluation of lymphedema","volume":"44","author":"Szuba A","year":"2003","journal-title":"J Nucl Med"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"1","article-title":"The diagnosis and treatment of peripheral lymphedema: 2013 consensus document of the International Society of Lymphology","volume":"46","year":"2013","journal-title":"Lymphology"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13036"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.10190"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.remn.2018.06.008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1099555"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/wjnm.WJNM_5_20"}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.12730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T09:43:40Z","timestamp":1764150220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.12730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/cob.12730"],"URL":"https:\/\/doi.org\/10.1111\/cob.12730","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"type":"print","value":"1758-8103"},{"type":"electronic","value":"1758-8111"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"2023-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12730"}}