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The secondary aim was to assess whether changes in SBP with GLP\u20101RAs are associated with weight change. MEDLINE and Cochrane were searched until January 2022 for randomized control trials (RCTs) on patients with obesity, evaluating the impact of semaglutide, liraglutide, efpeglenatide, or exenatide on SBP. Separate analyses were done for trials with and without diabetes. Multivariate meta\u2010regression assessed if SBP changes with GLP\u20101RA varied based on weight change or follow\u2010up duration. Thirty\u2010five RCTs were included. Follow\u2010up duration ranged from 12 to 68\u2009weeks for T2DM and 12\u201356\u2009weeks for non\u2010T2DM patients. GLP\u20101RAs significantly lowered SBP for all patients (MD = \u22123.14 [\u22123.60; \u22122.68]). Subgroup analysis showed a significantly greater difference in SBP reduction for patients without diabetes (\u22123.80 [\u22124.24; \u22123.37]) when compared with patients with diabetes (\u22122.13 [\u22123.27; \u22121.00]). Among patients with diabetes, liraglutide &lt;\u20092 mg OD showed the greatest reduction in SBP (\u22123.78 [\u22126.27; \u22121.28]), while efpeglenatide \u2264\u20096 mg QW showed the greatest reduction in SBP (\u22126.00 [\u22129.89; \u22122.11]) in patients without diabetes. GLP\u20101RAs result in mild reductions in SBP in patients with obesity. The change in SBP varies only slightly by the drug\u2013dose combination and appears to be related to the amount of weight loss.<\/jats:p>","DOI":"10.1111\/cob.70012","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T05:41:34Z","timestamp":1745386894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of glucagon\u2010like peptide 1 receptor agonists on systolic blood pressure in patients with obesity, with or without diabetes: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"15","author":[{"given":"Abraish","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-8331","authenticated-orcid":false,"given":"Asad Ali","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shariq","family":"Usman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izza","family":"Shahid","sequence":"additional","affiliation":[{"name":"Division of Preventive Cardiology Houston Methodist Academic Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shahzeb","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prinka","family":"Perswani","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, Riverside School of Medicine  Riverside California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","first-page":"292","article-title":"Guideline for the prevention and control of type 2 diabetes in China (2017 edition)","volume":"38","author":"Association CS of D of CM","year":"2018","journal-title":"Chin J Pract Intern Med"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci18\u20100033"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA2032183\/SUPPL_FILE\/NEJMOA2032183_DATA\u2010SHARING.PDF"},{"key":"e_1_2_11_5_1","unstructured":"Overview|Semaglutide for managing overweight and obesity|Guidance|NICE. 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