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Building on the success of the inaugural event in 2022, this gathering served as a pivotal platform for attendees to delve into the latest scientific and clinical developments in hyperphagia and early\u2010onset obesity caused by rare melanocortin\u20104 receptor (MC4R) pathway disease. The central objective of the meeting was to explore the complexities of MC4R pathway\u2010related diseases and generate opportunities for collaborative dialogue among delegates for the advancement of this field. The event unfolded across three distinct sessions, with a dedicated focus on monogenic MC4R pathway disease, Bardet\u2010Biedl syndrome (BBS) and hypothalamic obesity, together with a discussion on the future of the field. Additionally, the agenda featured three insightful workshops designed to facilitate in\u2010depth discussions. One workshop focused on the genetics of monogenic MC4R pathway diseases, another scrutinised the genetics of BBS and the final workshop examined patient management through the exploration of clinical cases. As we reflect on the wealth of information disseminated and the collaborative spirit that permeated the meeting, it becomes clear that IMPROVE 2023 was not merely an assembly of professionals; it was a forum where the future of research in rare MC4R pathway diseases and patient care took centre stage. Here, we encapsulate the key insights, discussions, and initiatives that emerged from this important meeting.<\/jats:p>","DOI":"10.1111\/cob.70029","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:29:32Z","timestamp":1754008172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>IMPROVE<\/scp> 2023: The 2nd International Meeting on Pathway\u2010Related Obesity: Vision &amp; Evidence"],"prefix":"10.1111","volume":"15","author":[{"given":"Karine","family":"Cl\u00e9ment","sequence":"first","affiliation":[{"name":"INSERM, Nutrition and Obesity: Systemic Approaches, NutriOmics, Research Unit Sorbonne Universit\u00e9  Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris Nutrition Department, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica L. 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