{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:32:33Z","timestamp":1792211553894,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK123704"],"award-info":[{"award-number":["P30 DK123704"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM130457"],"award-info":[{"award-number":["P20 GM130457"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Given the potential for more rapid ethanol absorption in patients who have undergone bariatric surgery, we hypothesized that bariatric surgery is associated with risk for more severe alcohol\u2010related liver disease. Therefore, patients \u2265\u200918\u2009years with alcohol use disorder (AUD) after bariatric surgery were examined using TriNetX (2010\u20132024). Propensity score matching (PSM) was used to compare patients with AUD following surgery to those with AUD without surgery. Primary outcomes included the likelihood of developing alcohol\u2010associated hepatitis, cirrhosis, or any clinical decompensation event. All\u2010cause mortality was a secondary outcome. Of 2\u2009241\u2009137 patients with AUD, 15 808 patients had AUD following bariatric surgery. Before PSM, patients undergoing surgery were generally older, predominantly female, with a higher body mass index (BMI) than those with AUD without surgery. After PSM, each cohort had 15\u2009808 patients (mean [SD] age, 51 [13] years; 70% women). Patients with AUD following bariatric surgery had increased odds of acute alcohol\u2010associated hepatitis (OR\u2009=\u20091.67, 95% CI: 1.51\u20131.85;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), alcohol\u2010associated cirrhosis (OR\u2009=\u20091.49, 95% CI: 1.37\u20131.52;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), liver\u2010related decompensation events (OR\u2009=\u20091.51, 95% CI: 1.39\u20131.64;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and all\u2010cause mortality (OR\u2009=\u20091.13, 95% CI: 1.07\u20131.20;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) than those with AUD without surgery. The data suggest an increased risk of severe alcohol\u2010related liver disease in patients with AUD subsequent to bariatric surgery.\n                  <\/jats:p>","DOI":"10.1111\/cob.70041","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T06:49:37Z","timestamp":1755758977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Severe Alcohol\u2010Related Liver Disease Following Bariatric Surgery"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0641-1278","authenticated-orcid":false,"given":"Ahmed","family":"Ibrahim","sequence":"first","affiliation":[{"name":"The Digestive Disease Research Center, Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don C.","family":"Rockey","sequence":"additional","affiliation":[{"name":"The Digestive Disease Research Center, Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.09.041"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.14.1724"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066603"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.03.048"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2008.01.004"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.6147"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200111"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2007.07.003"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010010\u20100136\u20109"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.09.020"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21839"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.03.16"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2007.03.004"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.04.004"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16806"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010023\u201007876\u20107"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010021\u201007076\u20101"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.70007"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010024\u201007565\u2010y"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010019\u20101070\u20108"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102125.2002.01698.x"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2013.02.002"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2022.07.019"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010013\u20100884\u20104"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13441"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.159863"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.006"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.4158\/GL\u20102019\u20100406"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.12.003"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2014.09.005"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12798"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607195019004258"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2006.03003.x"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.07.005"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.7.830"}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:49:13Z","timestamp":1762840153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.70041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/cob.70041"],"URL":"https:\/\/doi.org\/10.1111\/cob.70041","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"value":"1758-8103","type":"print"},{"value":"1758-8111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]},"assertion":[{"value":"2025-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70041"}}