{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:56:43Z","timestamp":1791899803284,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Childhood obesity is associated with adverse health and psychosocial outcomes, often persisting into adulthood. Hospital\u2010based lifestyle interventions may provide intensive support, but evidence on long\u2010term effectiveness is limited. To evaluate changes in Body Mass Index z\u2010score (BMIz) among children and adolescents with overweight and obesity participating in a hospital\u2010based intervention compared to matched controls. This matched prospective cohort study includes children and adolescents aged 5\u201315\u2009years. The intervention consisted of a family\u2010centered hospital\u2010based lifestyle program focusing on diet, physical activity, sleep and screen time management. Controls were matched on age, sex, weight category, and calendar year. BMI trajectories were analyzed using mixed effects models with linear splines, adjusting for socioeconomic factors from national registries. A total sample size of 1897 children and adolescents was included (325 intervention, 1572 controls). The intervention group achieved a higher reduction in BMIz during the first 6\u2009months (\u22120.74 SD\/years, 95% CI: \u22120.89; \u22120.60) and up to 12\u2009months (\u22120.31 SD\/years, \u22120.45; \u22120.16), compared to controls. From 12 to 36\u2009months, a rebound in BMIz occurred (0.14, SD\/years, 0.10; 0.17), and continued to rise through 72\u2009months. The intervention was associated with improvements in BMIz up to 12\u2009months after the intervention. However, the effects were not sustained at 6\u2009years of follow\u2010up.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.Gov<\/jats:ext-link>\n                    identifier: NCT05790174\n                  <\/jats:p>","DOI":"10.1111\/cob.70052","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:28:24Z","timestamp":1762129704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Effect of a Hospital\u2010Based Intervention Program on\n                    <scp>BMI<\/scp>\n                    Trajectories in Danish Children and Adolescents With Overweight and Obesity: A 6\u2010Year Follow\u2010Up"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5163-7728","authenticated-orcid":false,"given":"Mette","family":"Fogh","sequence":"first","affiliation":[{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0627-1237","authenticated-orcid":false,"given":"Jane Nautrup","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-8924","authenticated-orcid":false,"given":"Rasmus M\u00f8ller","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Pediatrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6423-383X","authenticated-orcid":false,"given":"Eeva\u2010Liisa","family":"R\u00f8ssell","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9803-553X","authenticated-orcid":false,"given":"Marianne","family":"Eg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Regional Hospital Viborg  Viborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-7254","authenticated-orcid":false,"given":"Helle Terkildsen","family":"Maindal","sequence":"additional","affiliation":[{"name":"Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7542-6853","authenticated-orcid":false,"given":"Gunnar","family":"Toft","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-2351","authenticated-orcid":false,"given":"Henrik","family":"St\u00f8vring","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"},{"name":"Clinical Pharmacology, Pharmacy and Environmental Medicine University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-5467","authenticated-orcid":false,"given":"Jens Meldgaard","family":"Bruun","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Danish National Center for Obesity  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1363"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2019.01.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713231"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13641"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-022-01326-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2024.04.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32129-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00047-X"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-020-01342-1"},{"key":"e_1_2_9_11_1","unstructured":"J. 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Preventive Healthcare Services for Children and Adolescents \u201d(2024) https:\/\/lifeindenmark.borger.dk\/healthcare\/preventive\u2010options\/preventive\u2010healthcare\u2010services\u2010for\u2010children\u2010and\u2010adolescents#."},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S314959"}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cob.70052","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:12:52Z","timestamp":1770707572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.70052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,2]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/cob.70052"],"URL":"https:\/\/doi.org\/10.1111\/cob.70052","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"value":"1758-8103","type":"print"},{"value":"1758-8111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,2]]},"assertion":[{"value":"2025-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70052"}}