{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:46:10Z","timestamp":1792320370127,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RA) such as semaglutide, liraglutide and tirzepatide are effective for obesity and type 2 diabetes mellitus (T2DM) but may predispose users to micronutrient deficiencies through appetite suppression, delayed gastric emptying and altered absorption. Given the rapid rise in GLP\u20101RA use, clarifying their nutritional impact is clinically important. We conducted a structured search of PubMed and the Cochrane Database (January 2019\u2013May 2025) for adult studies evaluating nutritional or micronutrient outcomes during GLP\u20101RA therapy. Paediatric studies, those lacking nutrient endpoints, and review articles were excluded. Methods followed SANRA and PRISMA\u2010ScR guidance, and data were synthesised descriptively. Six studies met the inclusion criteria, encompassing 480\u2009825 adults. Vitamin D deficiency was the most common abnormality, occurring in 7.5% at 6\u2009months and 13.6% at 12\u2009months. Iron depletion was frequent, with GLP\u20101RA users demonstrating 26%\u201330% lower ferritin levels than SGLT2 inhibitor comparators. More than 60% of users consumed below estimated requirements for calcium and iron, and vitamin D intake averaged 20% of recommendations. Protein and calcium insufficiency contributed to lean mass loss, while thiamine and cobalamin deficits increased over time. GLP\u20101RA therapy is associated with meaningful nutritional deficiencies. Targeted nutritional assessment and individualised laboratory evaluation may be appropriate for patients at increased risk of malnutrition. Findings are mainly derived from observational datasets, and causality between GLP\u20101RA therapy and nutritional deficiencies cannot be definitively established.<\/jats:p>","DOI":"10.1111\/cob.70070","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:43:34Z","timestamp":1768815814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Micronutrient and Nutritional Deficiencies Associated With\n                    <scp>GLP<\/scp>\n                    \u20101 Receptor Agonist Therapy: A Narrative Review"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6287-6354","authenticated-orcid":false,"given":"Jorge","family":"Urbina","sequence":"first","affiliation":[{"name":"Universidad Aut\u00f3noma de Guadalajara  Guadalajara Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Eduardo","family":"Salinas\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico de Estudios Superiores de Monterrey Campus Monterrey  Monterrey Nuevo Le\u00f3n M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Valenciano","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Guadalajara  Guadalajara Jalisco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9892-4708","authenticated-orcid":false,"given":"Benjamin","family":"Clapp","sequence":"additional","affiliation":[{"name":"Department of Surgery Texas Tech University Health Sciences Center  El Paso Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS\u201024\u201001590"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20100407.70082"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obpill.2025.100237"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.06.03.25328908"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16368"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc\u20102022\u2010003300"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2025.241224"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1566498"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obpill.2025.100244"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.61783"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.14309\/01.ajg.0001048128.46369.17"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430\u2010025\u201001653\u20107"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15728"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22719"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.24336"}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cob.70070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:12:57Z","timestamp":1770707577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.70070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/cob.70070"],"URL":"https:\/\/doi.org\/10.1111\/cob.70070","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"value":"1758-8103","type":"print"},{"value":"1758-8111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]},"assertion":[{"value":"2025-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70070"}}