{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:58:08Z","timestamp":1775894288617,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024075","name":"Region Syddanmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obstructive sleep apnea (OSA) is associated with chronic obstructive pulmonary disease (COPD) and obesity, and all three are linked to reduced health\u2010related quality of life (HRQoL). Coexistence of OSA and COPD increases morbidity and mortality compared to each condition alone. Liraglutide, a glucagon\u2010like peptide 1 receptor agonist, may influence respiratory and HRQoL outcomes. In this secondary exploratory analysis of a randomised controlled trial including individuals with overweight or obesity and COPD, we evaluated effects of liraglutide on OSA prevalence and severity, daytime sleepiness (Epworth Sleepiness Scale, ESS), and HRQoL (Short Form\u201036 version 2, SF\u201036v2). In a double\u2010blinded randomised controlled trial, 40 participants with overweight or obesity and COPD from two outpatient clinics were randomised to liraglutide (3.0\u2009mg, subcutaneous) or placebo for 40\u2009weeks. Cardiorespiratory monitoring, SF\u201036v2 and ESS questionnaires were conducted at baseline and end of treatment. OSA was diagnosed in 84% of participants (70% in the liraglutide group and 85% in the placebo group). Compared to placebo, liraglutide significantly reduced OSA severity, with mean baseline\u2010adjusted differences of \u22129.87 events\/h (\u03b2 95% CI \u221219.5; \u22120.247,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.044) in Apnea\u2013Hypopnea Index and \u221210.16 events\/h (\u03b2 95% CI \u221219.29; \u22121.03,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.029) in Oxygen Desaturation Index. ESS scores did not change significantly. Significant improvements were observed in the SF\u201036v2 subdomains General Health Perception and Role Physical. OSA is common among individuals with overweight or obesity and COPD. Forty weeks of liraglutide treatment were associated with reduced OSA severity and improvements in selected HRQoL domains in this population.\n                  <\/jats:p>","DOI":"10.1111\/cob.70079","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:40:21Z","timestamp":1774309221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory Analysis of Liraglutide Effects on Obstructive Sleep Apnea and Health\u2010Related Quality of Life in Individuals With Obesity and\n                    <scp>COPD<\/scp>\n                    : A Secondary Analysis of a Randomised Controlled Trial"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2584-8142","authenticated-orcid":false,"given":"Sofie Krogh","family":"Wolsing","sequence":"first","affiliation":[{"name":"Department of Medicine University Hospital of Southern Denmark  Vejle Denmark"},{"name":"Department of Regional Health Research Faculty of Health Sciences, University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse Dudu Altintas","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Medicine Regional Hospital Horsens  Horsens Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus Bogh","family":"Juhl","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research Faculty of Health Sciences, University of Southern Denmark  Odense Denmark"},{"name":"Department of Medicine University Hospital of Southern Denmark  Esbjerg Denmark"},{"name":"Steno Diabetes Center  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research Faculty of Health Sciences, University of Southern Denmark  Odense Denmark"},{"name":"Department of Nuclear Medicine Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben Tranborg","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital of Southern Denmark  Esbjerg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Else\u2010Marie","family":"Bladbjerg","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research Faculty of Health Sciences, University of Southern Denmark  Odense Denmark"},{"name":"Unit for Thrombosis Research, Department of Clinical Biochemistry University Hospital of Southern Denmark  Esbjerg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-3463","authenticated-orcid":false,"given":"Ole","family":"Hilberg","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital of Southern Denmark  Vejle Denmark"},{"name":"Department of Regional Health Research Faculty of Health Sciences, University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2021.1884213"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102021\u2010069679"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2018.1509951"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2017.1267570"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2021.1950663"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13175"},{"issue":"5","key":"e_1_2_11_8_1","first-page":"355","article-title":"Diagnosis and Treatment of Obstructive Sleep Apnea in Adults","volume":"94","author":"Semelka 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The Epworth Sleepiness Scale 2022 https:\/\/epworthsleepinessscale.com\/about\u2010the\u2010ess\/."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010020\u201001417\u2010w"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2000.17"},{"key":"e_1_2_11_25_1","volume-title":"36\u2010Item Short Form Survey (SF\u201036)","author":"RAND Corporation","year":"2022"},{"key":"e_1_2_11_26_1","volume-title":"36\u2010Item Short Form Survey (SF\u201036) Scoring Instructions","author":"RAND Corporation","year":"2022"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650\u2010199206000\u201000002"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2016.52"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2024.2437525"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010022\u201002768\u2010y"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsae280"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2025.02.010"},{"issue":"2","key":"e_1_2_11_33_1","first-page":"1","article-title":"Sleep Apnoea in Patients Undergoing Bariatric Surgery","volume":"65","author":"Lage\u2010Hansen P. 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