{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:12Z","timestamp":1787014032678,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003451","name":"Euskal Herriko Unibertsitatea","doi-asserted-by":"publisher","award":["EHU14\/08"],"award-info":[{"award-number":["EHU14\/08"]}],"id":[{"id":"10.13039\/501100003451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003451","name":"Euskal Herriko Unibertsitatea","doi-asserted-by":"publisher","award":["PPGA18\/15"],"award-info":[{"award-number":["PPGA18\/15"]}],"id":[{"id":"10.13039\/501100003451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hyperleptinaemia is an emerging mechanism involved in the pathogenesis of obesity\u2010related primary hypertension (HTN). This substudy from a large clinical trial aimed to determine differences in [leptin] in physically inactive adults (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200969, 46.4% women) with HTN and living with overweight or obesity following a 16\u2010week supervised aerobic exercise training (EX group, 2\u2009days\/week) intervention with an attention control (AC, only physical advice) group, both combined with a hypocaloric diet; to analyse whether the changes observed after the intervention were maintained after 6\u2009months (6M); and to explore differences and potential mechanisms affected by sex. Cardiorespiratory fitness and body composition evaluation, and biochemical measurements were conducted. After the intervention [leptin] decreased in both groups (EX, 36%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003; AC, 23%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.06), returning to baseline concentrations after 6M of follow\u2010up in both groups. Changes over time were similar in both sexes, with no significant time\u2009\u00d7\u2009group interaction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). For all participants, body mass index was the only factor independently associated with [leptin] (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.339,\n                    <jats:italic>B<\/jats:italic>\n                    \u2009=\u20092.11, SE\u2009=\u20090.53), explaining 12% of the variability (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Among women, waist\u2010to\u2010hip ratio (12%,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.365,\n                    <jats:italic>B<\/jats:italic>\n                    \u2009=\u2009135.8, SE\u2009=\u200959.4) and fat\u2010free mass (11%,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.443,\n                    <jats:italic>B<\/jats:italic>\n                    \u2009=\u2009\u22122.33, SE\u2009=\u2009\u22122.27) additionally and independently explained leptin variability (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). A hypocaloric diet combined with supervised exercise appears to be an effective strategy for regulating [leptin] and improving metabolic health in individuals with HTN and overweight or obesity. The influence of fat distribution on leptin dynamics in women calls for research to consider sexual dimorphism.\n                  <\/jats:p>","DOI":"10.1111\/cob.70080","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:15:33Z","timestamp":1777943733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight\/Obesity: Results From\u00a0the\u00a0\n                    <scp>EXERDIET<\/scp>\n                    \u2010\n                    <scp>HTA<\/scp>\n                    Trial"],"prefix":"10.1111","volume":"16","author":[{"given":"Virginia A.","family":"Aparicio","sequence":"first","affiliation":[{"name":"Department of Physiology Institute of Nutrition and Food Technology, Biomedical Research Centre, Sport and Health Research Centre, University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Corres","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, Faculty of Education and Sport\u2010Physical Activity and Sport Sciences Section University of the Basque Country (UPV\/EHU)  Vitoria\u2010Gasteiz Araba\/\u00c1lava, Basque Country Spain"},{"name":"Bioaraba Health Research Institute Physical Activity, Exercise, and Health Group  Vitoria\u2010Gasteiz Basque Country Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1571-8408","authenticated-orcid":false,"given":"Ilargi","family":"Gorostegi\u2010Anduaga","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, Faculty of Education and Sport\u2010Physical Activity and Sport Sciences Section University of the Basque Country (UPV\/EHU)  Vitoria\u2010Gasteiz Araba\/\u00c1lava, Basque Country Spain"},{"name":"Bioaraba Health Research Institute Physical Activity, Exercise, and Health Group  Vitoria\u2010Gasteiz Basque Country Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Margareto","sequence":"additional","affiliation":[{"name":"TECNALIA, Basque Research and Technology Alliance (BRTA)  Vitoria\u2010Gasteiz Basque Country Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Maldonado\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport, Faculty of Education and Sport\u2010Physical Activity and Sport Sciences Section University of the Basque Country (UPV\/EHU)  Vitoria\u2010Gasteiz Araba\/\u00c1lava, Basque Country Spain"},{"name":"Bioaraba Health Research Institute Physical Activity, Exercise, and Health Group  Vitoria\u2010Gasteiz Basque Country 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