{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:15:53Z","timestamp":1788189353528,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The dual GLP\u20101\/GIP agonist tirzepatide is a highly effective anti\u2010obesity therapy. While promising, it is associated with potential adverse effects, including thyroid disease reported in animal models. Due to limited human data, this study seeks to identify and characterise risk factors for thyroid disease development in patients undergoing 1\u2009year of tirzepatide treatment. This study retrospectively analysed medical records of patients completing a 12\u2010month course of tirzepatide (2.5\u201315\u2009mg weekly) between September 2023 and September 2024. The primary endpoint is the development or worsening of any thyroid disease including DIT, Hashimoto thyroiditis, Graves' disease, benign neoplasms, goitre, and thyroid cancer. In 527 patients on tirzepatide, 28 (5.3%) developed or had progression of thyroid disease. The most frequent diagnoses were Nodular\/Goitre Disease and Drug\u2010Induced Thyroiditis. Multivariate analysis showed that a history of End\u2010Stage Renal Disease (OR\u2009=\u20092.94) and baseline thyroid disease (OR\u2009=\u20093.78) were significant risk factors. Baseline thyroid disease and end\u2010stage renal disease are significantly associated with an increased risk of new or recurrent thyroid disorders during tirzepatide treatment. These conditions should be classified as high risk, warranting periodic thyroid testing and further large\u2010scale prospective validation.<\/jats:p>","DOI":"10.1111\/cob.70084","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:45:19Z","timestamp":1779093919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Tirzepatide Therapy on Thyroid Disease: Understanding Risks and Emerging Insights"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5289-6546","authenticated-orcid":false,"given":"Emiliano G.","family":"Manueli Laos","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of General, Minimally Invasive &amp; Robotic Surgery University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Serafica","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General, Minimally Invasive &amp; Robotic Surgery University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5273-6602","authenticated-orcid":false,"given":"Andres","family":"Fontaine\u2010Nicola","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiothoracic Surgery University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General, Minimally Invasive &amp; Robotic Surgery University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-6986","authenticated-orcid":false,"given":"Khaled","family":"Abdelhady","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiothoracic Surgery University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reed","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General, Minimally Invasive &amp; Robotic Surgery University of Illinois Chicago  Chicago Illinois USA"},{"name":"Department of Medicine University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-0559","authenticated-orcid":false,"given":"Francisco","family":"Schlottmann","sequence":"additional","affiliation":[{"name":"Department of Surgery Hospital Alem\u00e1n  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Pirzada","sequence":"additional","affiliation":[{"name":"Institute for Minority Health Research, University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario A.","family":"Masrur","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General, Minimally Invasive &amp; Robotic Surgery University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"CDC \u201cAdult Obesity Facts. 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