{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T02:02:42Z","timestamp":1779760962100,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity in pregnancy is a well\u2010established risk factor for adverse maternal and neonatal outcomes, including gestational diabetes mellitus (GDM). This study aimed to examine the effects of lifestyle intervention during pregnancy on the cardio\u2010metabolic protein profile and its association with maternal and neonatal health. The Lifestyle in Pregnancy (LiP) study was a randomised controlled trial conducted between 2007 and 2010 in Denmark. It included 360 pregnant women with obesity (BMI 30\u201345\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), aged 18\u201340\u2009years, who were allocated to either a lifestyle intervention (dietary counselling, physical activity program, free fitness club membership) or standard care. Fasting serum samples from 303 women were collected at 12\u201315 and 28\u201330\u2009weeks' gestation and analysed using a 26\u2010plex cardio\u2010metabolic proteomics assay. When comparing the cardio\u2010metabolic protein profiles between the intervention and control groups before and after the intervention in pregnancy, we found that in late pregnancy the levels of two proteins, vitronectin and vitamin D\u2010binding protein, were significantly lower in the intervention group. In the total cohort, elevated vitronectin was associated with a higher risk of GDM (adjusted odds ratio\u2009=\u20091.45 (95% CI: 1.06\u20131.98),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) and neonatal intensive care unit (NICU) admissions (adjusted odds ratio\u2009=\u20091.68 (95% CI: 1.03\u20132.73),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.037). Vitronectin may represent a modifiable biomarker linked to metabolic dysfunction in pregnant women with obesity, suggesting a potential underlying pathway by which lifestyle interventions could improve pregnancy outcomes.\n                  <\/jats:p>","DOI":"10.1111\/cob.70085","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:45:13Z","timestamp":1779371113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lifestyle Intervention During Pregnancy Is Associated With Favourable Changes of Vitronectin in Women With Obesity: Results From the Randomised\n                    <scp>LiP<\/scp>\n                    Trial"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-5925","authenticated-orcid":false,"given":"Birgitte Moeller","family":"Luef","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-7344","authenticated-orcid":false,"given":"Katrine S\u00f8lling Borlund","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-8962","authenticated-orcid":false,"given":"Lasse M\u00f8llegaard","family":"Obel","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Cardiothoracic and Vascular Surgery Odense University Hospital  Odense Denmark"},{"name":"Department of Biochemistry and Immunology Lillebaelt Hospital, University Hospital of Southern Denmark  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1419-0223","authenticated-orcid":false,"given":"Louise Laage","family":"Stentebjerg","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-0805","authenticated-orcid":false,"given":"Per Glud","family":"Ovesen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-3034","authenticated-orcid":false,"given":"Patrick M.","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5222-2535","authenticated-orcid":false,"given":"Jan Stener","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3298-9824","authenticated-orcid":false,"given":"Dorte M\u00f8ller","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Steno Diabetes Center Odense, Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-6053","authenticated-orcid":false,"given":"Christina Anne","family":"Vinter","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Steno Diabetes Center Odense, Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-590X","authenticated-orcid":false,"given":"Martin","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Clinical Biochemistry Odense University Hospital  Odense Denmark"},{"name":"Steno Diabetes Center Odense, Odense University Hospital  Odense 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