{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T03:00:43Z","timestamp":1785121243523,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The aims of this study were to compare baseline Impact of Weight on Quality of Life\u2013Lite Clinical Trials Version (IWQOL\u2010Lite\u2010CT) scores between adults with obesity participating in either observational or clinical studies and to conduct a psychometric evaluation of the IWQOL\u2010Lite\u2010CT in the context of observational research. Analyses of covariance were used to compare baseline IWQOL\u2010Lite\u2010CT Total, Physical, Physical Function, and Psychosocial composite scores between participants with a body mass index (BMI) \u2265\u200930 in a US longitudinal survey (an observational study) and a multinational phase 3a study of subcutaneous semaglutide 2.4\u2009mg for weight management (STEP 1). Data from the longitudinal survey were also used to evaluate the psychometric properties of the IWQOL\u2010Lite\u2010CT composite scores. Adjusting for BMI, age, and sex, on average, participants in the longitudinal survey scored lower than STEP 1 participants at baseline by 23.4 points on the IWQOL\u2010Lite\u2010CT Total, 20.7 on the Physical composite, 20.3 on the Physical Function composite, and 24.8 on the Psychosocial composite. While the internal consistency, test\u2013retest reliability, and construct validity of the IWQOL\u2010Lite\u2010CT composite scores were confirmed in the longitudinal survey, responsiveness analyses were limited by small changes in weight. The weight\u2010related functioning of US individuals with obesity who participated in a longitudinal survey was more limited than that of participants in the STEP 1 clinical trial. Psychometric results support use of the IWQOL\u2010Lite\u2010CT in observational research in addition to the clinical trial setting.<\/jats:p>","DOI":"10.1111\/cob.70087","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:30:34Z","timestamp":1780529434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implementation of the\n                    <scp>IWQOL<\/scp>\n                    \u2010Lite\u2010\n                    <scp>CT<\/scp>\n                    in Observational Research: Comparison of Baseline Scores With a Clinical Trial Population and Psychometric Evaluation"],"prefix":"10.1111","volume":"16","author":[{"given":"Lisa von Huth","family":"Smith","sequence":"first","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Qin","sequence":"additional","affiliation":[{"name":"RTI Health Solutions  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidsel Marie Bernt","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dane","family":"Korver","sequence":"additional","affiliation":[{"name":"RTI Health Solutions  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Yarr","sequence":"additional","affiliation":[{"name":"RTI Health Solutions  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheri E.","family":"Fehnel","sequence":"additional","affiliation":[{"name":"RTI Health Solutions  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-2131","authenticated-orcid":false,"given":"Ronette L.","family":"Kolotkin","sequence":"additional","affiliation":[{"name":"Quality of Life Consulting  Durham North Carolina USA"},{"name":"Duke Family Medicine and Community Health, Duke University School of Medicine  Durham North Carolina USA"},{"name":"Faculty of Health and Social Sciences, Western Norway University of Applied Sciences  F\u00f8rde Norway"},{"name":"Morbid Obesity Centre, Vestfold Hospital Trust  T\u00f8nsberg Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12203"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2016.04.016"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(24)00316\u20104"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.13"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12197"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12310"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12477"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16046"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15620"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12387"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.70015"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.00978"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v039.i08"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273170802285941"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02310555"},{"key":"e_1_2_11_18_1","volume-title":"Test Theory: A Unified Treatment","author":"McDonald R. 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Guidance for Industry(2025) https:\/\/www.fda.gov\/media\/71252\/download."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12589"}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cob.70087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T02:52:55Z","timestamp":1785120775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.70087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/cob.70087"],"URL":"https:\/\/doi.org\/10.1111\/cob.70087","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"value":"1758-8103","type":"print"},{"value":"1758-8111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"assertion":[{"value":"2025-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70087"}}