{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T03:00:47Z","timestamp":1785121247565,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The timing of obesity onset may influence long\u2010term cardiovascular risk. Whether obesity beginning in early adulthood differs from obesity acquired later in life with respect to cardiometabolic and cardiovascular outcomes remains uncertain. We analysed adults with obesity (BMI \u2265\u200930\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) from the National Health and Nutrition Examination Survey (NHANES) 2017\u20132020. Participants were classified as having early\u2010onset obesity (with obesity at approximately age 25) or adult\u2010onset obesity (with obesity at study enrolment but not at age 25). Primary outcomes included measured hypertension and a composite of cardiovascular disease (CVD) (congestive heart failure [CHF], coronary heart disease, angina, myocardial infarction or stroke). The weighted population represented 19.4 million U.S. adults with obesity, including 2.56 million with early\u2010onset obesity. Adjusted cardiometabolic measures did not differ. CHF was more common with early\u2010onset obesity (13.5% vs. 6.6%), and adult\u2010onset obesity was associated with lower odds of CHF (adjusted OR: 0.43, 95% CI: 0.23\u20130.82). No differences were observed for coronary heart disease, angina, myocardial infarction, stroke or hard CVD. Among U.S. adults with obesity, early\u2010onset obesity is associated with a higher burden of CHF, suggesting a potential role of cumulative obesity exposure in heart failure development.\n                  <\/jats:p>","DOI":"10.1111\/cob.70091","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:49:33Z","timestamp":1781257773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early\u2010Onset Obesity and Heart Failure Burden Independent of Cardiometabolic Risk Factors"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-004X","authenticated-orcid":false,"given":"Shiza","family":"Sarfraz","sequence":"first","affiliation":[{"name":"Department of Medicine East Carolina University\/Brody School of Medicine  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer Haider","family":"Cheema","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Zayam","family":"Tayyab","sequence":"additional","affiliation":[{"name":"Department of Medicine Al\u2010Aleem Medical College  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-9197","authenticated-orcid":false,"given":"Hassam","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Medicine East Carolina University\/Brody School of Medicine  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harigopal","family":"Sandhyavenu","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1037"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab454"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029617"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316101"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.02.086"},{"key":"e_1_2_8_9_1","unstructured":"CDC \u201cNational Health and Nutrition Examination Survey \u201d2025 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