{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T03:00:41Z","timestamp":1785121241987,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Overweight and obesity are global health concerns linked to impaired female fertility. Weight\u2010lowering drugs are an alternative for achieving weight loss; however, their effect on natural female fertility is unclear. A systematic review and meta\u2010analysis were conducted to summarise the literature on the effects of weight\u2010lowering drugs on ovulation, conception, pregnancy and live birth rates. Inclusion criteria comprised interventional and observational studies involving women with overweight or obesity receiving weight\u2010lowering drugs, compared with non\u2010users, lifestyle modifications or other medications. MEDLINE, Embase, CINAHL, CENTRAL and\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    were searched, yielding 2731 records. After screening, seven clinical trials were included (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009575), six of which were randomised. Sample sizes ranged from 40 to 120 women aged 25.9\u201329.7\u2009years. Six trials evaluated orlistat, while one assessed semaglutide. In four trials, orlistat was associated with a higher ovulation rate than lifestyle modifications. A meta\u2010analysis of ovulation rates comparing orlistat and metformin showed no significant difference (RR\u2009=\u20090.78, 95% CI: 0.41\u20131.49;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.45). Two studies reported pregnancy rates: one found a higher rate with orlistat compared to lifestyle modifications (23.3% vs. 6.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.044), and another showed that adding semaglutide to metformin increased the pregnancy rate compared to metformin alone (35% vs. 15%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Future studies should address current limitations and evaluate the effects of newer weight\u2010lowering drugs on natural pregnancy and live birth rates in adequately powered studies.\n                  <\/jats:p>","DOI":"10.1111\/cob.70092","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:55:15Z","timestamp":1781704515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Weight\u2010Lowering Drugs and Natural Female Fertility\u2014A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4313-5098","authenticated-orcid":false,"given":"Shaikha Jabor","family":"Alnaimi","sequence":"first","affiliation":[{"name":"Research Department of Practice and Policy, School of Pharmacy University College London  London UK"},{"name":"Pharmacy Department, Hamad bin Khalifa Medical City Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana Muwafag","family":"Alsugeir","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Imam Abdulrahman bin Faisal University  Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[{"name":"Research Department of Practice and Policy, School of Pharmacy University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Harvey","sequence":"additional","affiliation":[{"name":"Research Department of Pharmacology, School of Pharmacy University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Brauer","sequence":"additional","affiliation":[{"name":"Research Department of Practice and Policy, School of Pharmacy University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)02750\u20102"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1326546"},{"key":"e_1_2_11_4_1","unstructured":"National Institute for Health and Care Excellence \u201cObesity: Identification Assessment and Management \u201daccessed Oct 12 2024 https:\/\/www.nice.org.uk\/guidance\/cg189."},{"key":"e_1_2_11_5_1","unstructured":"NHS Dorset Clinical Commissioning Group \u201cCommissioning Statement on Use of Liraglutide (Saxenda) in Weight Management \u201d2025 https:\/\/nhsdorset.nhs.uk\/Downloads\/aboutus\/medicines\u2010management\/Other%20Guidelines\/Commissioning%20statement%20Liraglutide%20Saxenda%20Weight%20Management%20Dec%202020.pdf?utm_source=chatgpt.com."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12328"},{"key":"e_1_2_11_7_1","unstructured":"Medicines and Healthcare products Regulatory Agency \u201cOrlistat Safety Update \u201daccessed November 19 2024 https:\/\/www.gov.uk\/drug\u2010safety\u2010update\/orlistat\u2010safety\u2010update#:~:text=Xenical%20has%20been%20licensed%20since the%20supervision%20of%20a%20pharmacist."},{"issue":"3","key":"e_1_2_11_8_1","first-page":"S12","article-title":"Mode of Action of Orlistat","volume":"21","author":"Guerciolini R.","year":"1997","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000450904"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c477"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23152"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310449"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13325"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12217"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx027"},{"key":"e_1_2_11_16_1","unstructured":"PRISMA \u201cPRISMA Checklist \u201d2023 http:\/\/www.prisma\u2010statement.org\/PRISMAStatement\/Checklist.aspx."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.21608\/amj.2022.230460"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010011\u20109564\u20102"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974\u20101208.147492"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den454"},{"issue":"2","key":"e_1_2_11_22_1","first-page":"477","article-title":"Role of Orlistat Combined With Life Style in the Management of Obese Patients With Polycystic Ovarian Syndrome","volume":"12","author":"Munir S. 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