{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:00:06Z","timestamp":1790298006737,"version":"4.1.0"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This correspondence addresses the EXERDIET\u2010HTA substudy by Aparicio and colleagues, which concludes that 16\u2009weeks of aerobic exercise plus a hypocaloric DASH diet reduced serum leptin more than diet with activity counselling in hypertensive adults with overweight or obesity. Five concerns are raised: inference from within\u2010group\n                    <jats:italic>p<\/jats:italic>\n                    values despite a non\u2010significant time \u00d7 group interaction; pooling of three sub\u2010threshold exercise protocols; mislabelling of an active comparator as \u2018attention control\u2019; sevenfold attrition asymmetry analysed by complete\u2010case rather than intention\u2010to\u2010treat methods; and effectively complete reversion of leptin at 6\u2009months. A disaggregated, ITT re\u2010analysis would yield more conservative but more defensible conclusions.\n                  <\/jats:p>","DOI":"10.1111\/cob.70094","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:49:13Z","timestamp":1786582153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight\/Obesity: Results From the\n                    <scp>EXERDIET<\/scp>\n                    \u2010\n                    <scp>HTA<\/scp>\n                    Trial"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-1520","authenticated-orcid":false,"given":"Maajid Mohi Ud Din","family":"Malik","sequence":"first","affiliation":[{"name":"Dr. D.Y. Patil School of Allied Health Sciences, Dr. D.Y. Patil Vidyapeeth (Deemed to be University)  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_1_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.70080"},{"key":"e_1_2_1_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advnut.2022.10.001"},{"key":"e_1_2_1_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0288730"},{"key":"e_1_2_1_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_1_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-022-00207-1"}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cob.70094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:12:53Z","timestamp":1790295173000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.70094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/cob.70094"],"URL":"https:\/\/doi.org\/10.1111\/cob.70094","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"value":"1758-8103","type":"print"},{"value":"1758-8111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"2026-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70094"}}