{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T03:00:42Z","timestamp":1785121242528,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014565","name":"Bausch Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014565","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The prevalence of obesity is increasing worldwide, with approximately nine million people affected in Canada. Obesity is associated with high rates of morbidity and mortality as well as significant healthcare costs and economic burden. The primary therapeutic options for weight maintenance and treatment of weight regain include behaviour modification, lifestyle intervention and pharmacotherapy. This randomised, double\u2010blind, placebo\u2010controlled, crossover trial aimed to determine the effect of a fixed\u2010dose, extended\u2010release combination of naltrexone and bupropion (NB\u2010ER) (commonly known as Contrave) on weight maintenance and further weight loss following the intensive portion of a behaviour modification program. The results from this study demonstrate that after an intensive lifestyle intervention program, treatment with NB\u2010ER for six months prevented weight regain compared to placebo. Additionally, a greater proportion of subjects experienced weight maintenance and less absolute weight regain on NB\u2010ER compared to placebo, supporting the use of NB\u2010ER as an effective option for weight maintenance in patients with significant prior weight loss.<\/jats:p>","DOI":"10.1111\/cob.70099","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:27:22Z","timestamp":1784662042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Naltrexone\n                    <scp>HCl<\/scp>\n                    and Bupropion\n                    <scp>HCl<\/scp>\n                    (Contrave) Extended\u2010Release Tablet (\n                    <scp>NB<\/scp>\n                    \u2010\n                    <scp>ER<\/scp>\n                    ) for Weight Maintenance in Adult Patients After a 6\u2010Month Intensive Behaviour Modification Program Combined With Meal Replacements"],"prefix":"10.1111","volume":"16","author":[{"given":"V. Tony","family":"Chetty","sequence":"first","affiliation":[{"name":"Hamilton Regional Laboratory Medicine Program  Hamilton Ontario Canada"},{"name":"McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liviu","family":"Denescu","sequence":"additional","affiliation":[{"name":"Centre for Bariatric Excellence Guelph General Hospital  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Zevin","sequence":"additional","affiliation":[{"name":"Centre for Bariatric Excellence Kingston Health Sciences  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5464-8774","authenticated-orcid":false,"given":"Suzana","family":"Damjanovic","sequence":"additional","affiliation":[{"name":"The Research Institute of St Joe's  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-9668","authenticated-orcid":false,"given":"Iris M.","family":"Balodis","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research St Joseph's Healthcare  Hamilton Ontario Canada"},{"name":"Psychiatry and Behavioural Neurosciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adell","family":"Elsharif","sequence":"additional","affiliation":[{"name":"Centre for Bariatric Excellence Bariatric Medical Weight Management Clinic, St Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Foster","sequence":"additional","affiliation":[{"name":"Biostatistics Unit The Research Institute of St Joe's  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Obesity","author":"Panuganti K. 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