{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T03:00:42Z","timestamp":1785121242609,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006212","name":"Hellenic Cardiological Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010353","name":"Hellenic Atherosclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to evaluate the association between indices of adiposity and 20\u2010year cumulative incidence of type 2 diabetes (T2D) among apparently healthy adults participating in the ATTICA cohort study (2002\u20132022). The present analysis included data from 2000 individuals free of atherosclerotic cardiovascular disease (ASCVD) and T2D at baseline (age 43\u2009\u00b1\u200913\u2009years; 51% women). Sociodemographic, anthropometric, lifestyle, clinical, and biochemical parameters were collected at baseline and follow\u2010up examinations. Obesity\u2010related anthropometric indices, in terms of total and central adiposity, along with dysfunctional adipose tissue\u2010related indices, were measured. The 20\u2010year cumulative incidence of T2D was 26.3% (95% CI [24.4%, 28.3%]). All indices were independently associated with the 20\u2010year incidence of T2D, with an overall predictive accuracy of approximately 75%. With the exception of LAP (lipid accumulation product), all indices reflecting adipose tissue dysfunction demonstrated moderate discriminative accuracy for incident T2D (\n                    <jats:italic>C<\/jats:italic>\n                    \u2010statistic varied between 0.70 and 0.80) over the 20\u2010year follow\u2010up period, in line with obesity\u2010related anthropometric indices assessing total and central adiposity (\n                    <jats:italic>C<\/jats:italic>\n                    \u2010statistic 0.70\u20130.80). Obesity\u2010related anthropometric indices as well as dysfunctional adipose tissue\u2010related indices were moderately predictive of long\u2010term T2D onset, highlighting the complex role of increased body weight on glucose metabolism.\n                  <\/jats:p>","DOI":"10.1111\/cob.70100","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:45:25Z","timestamp":1784889925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Evaluation of Adiposity Indices on 20\u2010Year Cumulative Incidence of Type 2 Diabetes: The\n                    <scp>ATTICA<\/scp>\n                    Cohort Study (2002\u20132022)"],"prefix":"10.1111","volume":"16","author":[{"given":"Ioanna","family":"Kechagia","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Sciences &amp; Education Harokopio University  Athens Greece"},{"name":"Department of Clinical Dietetics\u2010Nutrition HYGEIA Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia\u2010Panagiota","family":"Giannakopoulou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Sciences &amp; Education Harokopio University  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios","family":"Barkas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School University of Ioannina  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2171-7337","authenticated-orcid":false,"given":"Mary","family":"Yannakoulia","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Sciences &amp; Education Harokopio University  Athens 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Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-153X","authenticated-orcid":false,"given":"Demosthenes","family":"Panagiotakos","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Sciences &amp; Education Harokopio University  Athens 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