{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:00:04Z","timestamp":1790298004392,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs), including semaglutide, are widely used for Type 2 diabetes mellitus (T2DM), obesity and related metabolic conditions. Evidence on potential neuropsychiatric effects remains inconsistent. This systematic review and meta\u2010analysis evaluated depression risk among patients receiving semaglutide. Following PRISMA 2020 guidelines, major biomedical databases, trial registries, pharmacovigilance databases, conference abstracts and grey literature were searched from inception to January 2026. Eligible studies included randomised controlled trials, observational studies, large database analyses and pharmacovigilance disproportionality studies involving patients receiving semaglutide. Risk of bias was assessed using ROBINS\u2010I and the Newcastle\u2013Ottawa Scale. The pooled risk ratio for depression was 1.25 (95% CI: 0.95\u20131.65;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200998%). For anxiety and suicidal ideation\/attempt, pooled risk ratios were 1.22 (95% CI: 0.93\u20131.60;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200999%) and 1.20 (95% CI: 0.90\u20131.62;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200992%), respectively. No statistically significant differences were observed between semaglutide and comparator\/placebo groups for outcomes. Pooled estimates did not show a statistically significant increase in depression, anxiety or suicidal ideation\/attempt among patients receiving semaglutide compared with comparator groups. However, the certainty of evidence was limited by substantial heterogeneity, risk of bias and reliance on heterogeneous data sources, including spontaneous\u2010reporting studies. These findings are reassuring but should be interpreted as the absence of a detected increased risk in the available evidence, rather than definitive proof of no psychiatric risk.\n                  <\/jats:p>","DOI":"10.1111\/cob.70105","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:38:23Z","timestamp":1786541903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Burden and Risk of Depression in Patients Receiving Semaglutide: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4000-9287","authenticated-orcid":false,"given":"Gaurab","family":"Bhaduri","sequence":"first","affiliation":[{"name":"Department of Diabetes &amp; Endocrinology Park View Super Speciality Hospital  Kolkata West Bengal India"},{"name":"Apollo Sugar Clinic  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4257-9982","authenticated-orcid":false,"given":"Shilanjan","family":"Roy","sequence":"additional","affiliation":[{"name":"Charnock Hospital  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8869-9351","authenticated-orcid":false,"given":"Anchin","family":"Kalia","sequence":"additional","affiliation":[{"name":"Department of Medicine Mahatma Gandhi Medical College and Hospital  Jaipur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8546-002X","authenticated-orcid":false,"given":"Rutul","family":"Gokalani","sequence":"additional","affiliation":[{"name":"AHC Diabetes Centre  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7293-8864","authenticated-orcid":false,"given":"Banshi","family":"Saboo","sequence":"additional","affiliation":[{"name":"DiaCare, Diabetes Care &amp; Hormone Clinic  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization \u201cDepressive Disorder (Depression) \u201d2025 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/depression."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167561"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11030176"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103363"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18030399"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201075965\u20102"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103385"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.4346"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2025.06.011"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102726"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096\u2010023\u201001694\u20107"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/02537176241246744"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2025.1394"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.70037"},{"key":"e_1_2_12_19_1","unstructured":"US Food and Drug Administration \u201cFDA Requests Removal of Suicidal Behavior and Ideation Warning From Glucagon\u2010Like Peptide\u20101 Receptor Agonist (GLP\u20101 RA) Medications \u201d2026 https:\/\/www.fda.gov\/drugs\/drug\u2010safety\u2010communications\/fda\u2010requests\u2010removal\u2010suicidal\u2010behavior\u2010and\u2010ideation\u2010warning\u2010glucagon\u2010peptide\u20101\u2010receptor\u2010agonist\u2010glp."},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261\u2010017\u20100601\u20105"}],"container-title":["Clinical Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cob.70105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cob.70105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:12:32Z","timestamp":1790295152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cob.70105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/cob.70105"],"URL":"https:\/\/doi.org\/10.1111\/cob.70105","archive":["Portico"],"relation":{},"ISSN":["1758-8103","1758-8111"],"issn-type":[{"value":"1758-8103","type":"print"},{"value":"1758-8111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"2026-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70105"}}