{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:00:05Z","timestamp":1790298005287,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This systematic review and meta\u2010analysis aimed to compare\u00a0the efficacy and safety of tirzepatide versus semaglutide for weight reduction in adults with overweight or obesity. We included randomised controlled trials and observational studies comparing tirzepatide and semaglutide with \u2265\u200924\u2009weeks of follow\u2010up. The primary outcome was percentage weight change from baseline. Secondary outcomes included absolute weight change, weight\u2010loss thresholds, HbA1c and safety outcomes. Ten studies including 41\u2009381 participants were analysed. Tirzepatide was associated with greater percentage weight reduction than semaglutide (MD \u22124.28 percentage points; 95% CI \u22125.28 to \u22123.28;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.00001) and greater absolute weight loss (MD \u22124.43\u2009kg; 95% CI \u22125.56 to \u22123.30;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.00001). Tirzepatide was also associated with a higher likelihood of achieving \u2265\u200910%, \u2265\u200915% and \u2265\u200920% weight loss, with no difference at \u2265\u20095%. HbA1c reduction was greater with tirzepatide (MD \u22120.29%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0002). Subgroup analyses by study design and type 2 diabetes status yielded consistent findings. There was no significant difference in treatment discontinuation due to adverse events (RR 1.28;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.54), whereas serious adverse events were more frequent with tirzepatide (RR 1.83;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007). Overall and gastrointestinal adverse events were similar between groups. Tirzepatide was associated with greater weight reduction, greater glycaemic benefit and a higher likelihood of achieving weight\u2010loss thresholds than semaglutide, but with a higher risk of serious adverse events.\n                  <\/jats:p>","DOI":"10.1111\/cob.70111","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:46:31Z","timestamp":1788158791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of Tirzepatide Versus Semaglutide for Weight Loss in Adults With Overweight or Obesity: A Systematic Review and Meta\u2010Analysis of Head\u2010to\u2010Head Studies"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9539-710X","authenticated-orcid":false,"given":"Giovanna Pagani","family":"Paccola","sequence":"first","affiliation":[{"name":"Faculdade de Medicina de Ja\u00fa Universidade do Oeste Paulista  Ja\u00fa S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Fernandes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ja\u00fa Universidade do Oeste Paulista  Ja\u00fa S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Men\u00e3o","family":"Mochetti","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Bauru Universidade de S\u00e3o Paulo  Bauru S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Pataro Marsola","family":"Razera","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ja\u00fa Universidade do Oeste Paulista  Ja\u00fa S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3060-6922","authenticated-orcid":false,"given":"Rafael","family":"Vecchi","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ja\u00fa Universidade do Oeste Paulista  Ja\u00fa S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan Canale Peres","family":"Montanher","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ja\u00fa Universidade do Oeste Paulista  Ja\u00fa S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Obesity and Overweight","author":"World Health 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