{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:00:08Z","timestamp":1790298008576,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Obesity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) and dual agonists have become pivotal options for obesity, but marked weight loss heterogeneity remains poorly understood. This meta\u2010regression analysis aimed to identify factors influencing this heterogeneity. We searched Medline, Embase, The Cochrane Library, and Web of Science up to February 1, 2026, enrolling 32 eligible trials (40\u2009408 participants) following PRISMA guidelines. Meta\u2010regression and subgroup analyses were performed using R software. Pooled analysis showed that GLP\u20101RAs and dual agonists achieved a weighted mean weight reduction of 9.36% (95% CI 7.92%\u201310.80%), with high interstudy heterogeneity (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200999.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Subgroup analyses revealed that GLP\u20101\/GIP dual agonists (tirzepatide) and longer treatment duration (\u2265\u200972\u2009weeks) yielded superior weight\u2010lowering effects. Meta\u2010regression demonstrated that baseline anxiety\/depression was positively associated with weight loss efficacy (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20092.44,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001,\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200981.34%). Comorbid Type 2 diabetes mellitus (T2DM), obstructive sleep apnea (OSA) and metabolic dysfunction\u2010associated fatty liver disease (MAFLD) were negatively correlated with treatment response (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Emotional state and metabolic comorbidities including T2DM, OSA and MAFLD are important influencing factors of the interindividual differences of weight loss efficacy of GLP\u20101RAs and dual agonists, providing evidence for personalized obesity management.\n                  <\/jats:p>","DOI":"10.1111\/cob.70112","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T03:31:39Z","timestamp":1789356699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Weight Reduction Heterogenicity and Mediators of\n                    <scp>GLP<\/scp>\n                    \u2010\n                    <scp>1RAs<\/scp>\n                    and Dual Agonists for Individuals With Obesity: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3953-8900","authenticated-orcid":false,"given":"Difei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-9483","authenticated-orcid":false,"given":"Ying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Peking University First Hospital  Beijing 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