{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:13:35Z","timestamp":1792088015622,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T00:00:00Z","timestamp":1363737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized <jats:italic>R<\/jats:italic>\u2010limonene has previously been patch tested in multicentre studies, giving 2\u20133% positive patch test reactions in consecutive patients.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To investigate whether oxidized <jats:italic>R<\/jats:italic>\u2010limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim\u2010OOHs), could be a useful tool for the detection of contact allergy in an international setting.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold>  Oxidized <jats:italic>R<\/jats:italic>\u2010limonene 3.0% (Lim\u2010OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Overall, 5.2% (range 2.3\u201312.1%) of the patients showed a positive patch test reaction to oxidized <jats:italic>R<\/jats:italic>\u2010limonene. Doubtful reactions were found in 7.0% of the patients (range 0\u201324%). Few irritant reactions were seen.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Oxidized <jats:italic>R<\/jats:italic>\u2010limonene at 3.0% pet. with a specified content of Lim\u2010OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized <jats:italic>R<\/jats:italic>\u2010limonene would not be informed of their fragrance allergy if this specific test had not been performed.<\/jats:p>","DOI":"10.1111\/cod.12036","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T05:44:23Z","timestamp":1363758263000},"page":"214-223","source":"Crossref","is-referenced-by-count":65,"title":["An international multicentre study on the allergenic activity of air\u2010oxidized <i>R<\/i>\u2010limonene"],"prefix":"10.1111","volume":"68","author":[{"given":"Johanna","family":"Br\u00e5red Christensson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Garcia\u2010Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Leok","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01418.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00302.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01287.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01088.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02037.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02269653"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01442.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx049831z"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.460504.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01262.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx700017v"},{"key":"e_1_2_7_13_2","first-page":"18","article-title":"Limonen \u2010 Dipenten, Citrus \u2010Ole und Citrus \u2010 Terpene: Teil I. 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