{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:52:08Z","timestamp":1791046328422,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:00:00Z","timestamp":1369180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> Delayed allergic hypersensitivity reactions have classically been described as type IV reactions, which are caused by T cells; however, the respective roles of CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> cells are yet to be defined. A central role for CD8<jats:sup>+<\/jats:sup> cytotoxic T cells as effector cells has been suggested.<\/jats:p><jats:p><jats:bold>Objectives<\/jats:bold> To determine the type of T cell involved in corticosteroid allergy.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> We analysed the kinetics of T cell recruitment and the cytokine production profile in positive patch tests of 27 corticosteroid\u2010sensitized patients, as compared with control sites and control subjects. Skin biopsies, collected at 8, 24 and 48 hr following drug application, were embedded in paraffin for histological and immunohistological staining, and, in some cases, also deep\u2010frozen for gene expression analyses.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> CD3<jats:sup>+<\/jats:sup> T cells were rapidly recruited in concert with the positivity of the patch test sites. High levels of interleukin (IL)\u20104, IL\u20105 and, to a lesser extent, interferon\u2010<jats:italic>\u03b3<\/jats:italic> suggested that both Th2 and Th1 cytokines were implicated. IL\u20104 was also produced by <jats:italic>\u03b3\u03b4<\/jats:italic> T cell receptor (TCR) lymphocytes.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> This study showed that, in allergic contact dermatitis caused by corticosteroids, the inflammatory infiltrate is composed of CD3<jats:sup>+<\/jats:sup> T cells with a predominant Th2 cytokine profile, among which IL\u20104 is also produced by <jats:italic>\u03b3\u03b4<\/jats:italic> TCR lymphocytes.<\/jats:p>","DOI":"10.1111\/cod.12040","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T11:05:46Z","timestamp":1369220746000},"page":"357-368","source":"Crossref","is-referenced-by-count":20,"title":["Characterization of the T cell response in allergic contact dermatitis caused by corticosteroids"],"prefix":"10.1111","volume":"68","author":[{"given":"Marie","family":"Baeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e8le","family":"Soria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Marot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Theate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Hendrickx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Van Belle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Tennstedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dachelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan","family":"Jaeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Pilette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Renauld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Van Baren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Rozi\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fan\u00e7ois","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Dumoutier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02038.x"},{"key":"e_1_2_6_3_2","first-page":"761","volume-title":"Clinical Aspects of Immunology","author":"Coombs R R A","year":"1975"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-8-200310210-00012"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02742.x"},{"key":"e_1_2_6_6_2","first-page":"763","article-title":"Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects","volume":"212","author":"Peiser M","journal-title":"Cell Mol Life Sci"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000300001"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02307.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01674.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32832d565c"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.352"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700174"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.9.5571"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.022"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282ef869e"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.25"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.4049\/jimmunol.135.6.3929","article-title":"Isolation and characterisation of Ni\u2010specific T cell clones from patients with Ni\u2010contact dermatitis","volume":"135","author":"Sinigaglia F","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02164.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.187"},{"key":"e_1_2_6_20_2","first-page":"37","article-title":"Contact allergy to nickel: patch test score correlates with IL\u20105, but not with IFN\u2010gamma nickel\u2010specific secretion by peripheral blood lymphocytes","volume":"16","author":"Czarnobilska E","year":"2009","journal-title":"Ann Agric Environ Med"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03226.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00749.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09400.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01602.x"},{"key":"e_1_2_6_25_2","first-page":"41","article-title":"Recommendation to include budesonide and tixocortol pivalate in the European standard series","volume":"43","author":"Isaksson M","year":"2000","journal-title":"Contact Dermatitis"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.00959.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114001"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00236-3"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2006.05048"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246526"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000086659"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100804"},{"key":"e_1_2_6_33_2","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.4049\/jimmunol.149.11.3503","article-title":"Gamma delta T cells assist alpha beta T cells in adoptive transfer of contact sensitivity","volume":"149","author":"Ptak W","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01570.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.05.022"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12040","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T08:45:42Z","timestamp":1700729142000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,22]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/cod.12040"],"URL":"https:\/\/doi.org\/10.1111\/cod.12040","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,22]]}}}