{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:12Z","timestamp":1791405192594,"version":"4.3.3"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:00:00Z","timestamp":1369180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> It has been suggested that interleukin (IL)\u201017 and IL\u201022 play important roles in the elicitation of human allergic contact dermatitis; however, the frequencies of T cell subtypes producing IL\u201017 and IL\u201022 in human allergic contact dermatitis are unknown.<\/jats:p><jats:p><jats:bold>Objectives<\/jats:bold> To determine the frequencies of CD4<jats:sup>+<\/jats:sup>, CD8<jats:sup>+<\/jats:sup> and <jats:italic>\u03b3\u03b4<\/jats:italic> T cells producing IL\u201017, IL\u201022 and interferon (IFN)\u2010<jats:italic>\u03b3<\/jats:italic> in the blood and skin from nickel\u2010allergic patients.<\/jats:p><jats:p><jats:bold>Patients\/materials\/methods<\/jats:bold> Blood samples were collected from 14 patients and 17 controls, and analysed by flow cytometry. Biopsies were taken from 5 patients and 6 controls, and analysed by immunohistochemistry and flow cytometry of skin lymphocytes.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> We found an increased frequency of <jats:italic>\u03b3\u03b4<\/jats:italic> T cells in the blood, but no differences in the distribution of cytokine\u2010producing CLA<jats:sup>+<\/jats:sup> T cell subtypes in nickel\u2010allergic patients as compared with controls. In nickel\u2010allergic patients, there was massive cellular infiltration dominated by CD4<jats:sup>+<\/jats:sup> T cells producing IL\u201017, IL\u201022 and IFN\u2010<jats:italic>\u03b3<\/jats:italic> in nickel\u2010challenged skin but not in vehicle\u2010challenged skin.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> CD4<jats:sup>+<\/jats:sup> T cells producing IL\u201017, IL\u201022 and IFN\u2010<jats:italic>\u03b3<\/jats:italic> are important effector cells in the eczematous reactions of nickel\u2010induced allergic contact dermatitis in humans.<\/jats:p>","DOI":"10.1111\/cod.12043","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T11:05:46Z","timestamp":1369220746000},"page":"339-347","source":"Crossref","is-referenced-by-count":74,"title":["CD4<sup>+<\/sup> T cells producing interleukin (IL)\u201017, IL\u201022 and interferon\u2010<i>\u03b3<\/i> are major effector T cells in nickel allergy"],"prefix":"10.1111","volume":"68","author":[{"given":"Beatrice","family":"Dyring\u2010Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Skov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne B.","family":"L\u00f8vendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bzorek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knud","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens\u2010Peter 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