{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:13:56Z","timestamp":1792088036204,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> In studies in Gothenburg, Sweden, in the 1990s of an aluminium hydroxide\u2010adsorbed pertussis toxoid vaccine, 745 of \u223c76 000 vaccinated children developed long\u2010lasting itchy subcutaneous nodules at the vaccination site. Of 495 children with itchy nodules patch tested for aluminium allergy, 376 (76%) were positive.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To study the prognosis of the vaccine\u2010induced aluminium allergy.<\/jats:p><jats:p><jats:bold>Patients and methods.<\/jats:bold> Two hundred and forty\u2010one children with demonstrated aluminium allergy in the previous study were patch tested again 5\u20139 years after the initial test, with the same procedure as used previously.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Contact allergy to aluminium was no longer demonstrable in 186 of the retested 241 children (77%). A negative test result was more common in children who no longer had itching at the vaccination site; it was also related to the age of the child, the time after the first aluminium\u2010adsorbed vaccine dose, and the strength of the reaction in the first test.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Patch test reactivity to aluminium seems to disappear or weaken with time.<\/jats:p>","DOI":"10.1111\/cod.12053","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T05:31:55Z","timestamp":1366608715000},"page":"286-292","source":"Crossref","is-referenced-by-count":57,"title":["Unexpected loss of contact allergy to aluminium induced by vaccine"],"prefix":"10.1111","volume":"68","author":[{"given":"Anette","family":"Gente 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